PMID: 8904598Oct 1, 1996

Decreased energy metabolism in brain stem during central respiratory depression in response to hypoxia

Journal of Applied Physiology
Joseph C LamannaN S Cherniack


Metabolic changes in the brain stem were measured at the time when oxygen deprivation-induced respiratory depression occurred. Eucapnic ventilation with 8% oxygen in vagotomized urethan-anesthetized rats resulted in cessation of respiratory drive, monitored by recording diaphragm electromyographic activity, on average within 11 min (range 5-27 min), presumably via central depressant mechanisms. At that time, the brain stems were frozen in situ for metabolic analyses. By using 20-microns lyophilized sections from frozen-fixed brain stem, microregional analyses of ATP, phosphocreatine, lactate, and intracellular pH were made from 1) the ventral portion of the nucleus gigantocellularis and the parapyramidal nucleus; 2) the compact and ventral portions of the nucleus ambiguus; 3) midline neurons; 4) nucleus tractus solitarii; and 5) the spinal trigeminal nucleus. At the time of respiratory depression, lactate was elevated threefold in all regions. Both ATP and phosphocreatine were decreased to 50 and 25% of control, respectively. Intracellular pH was more acidic by 0.2-0.4 unit in these regions but was relatively preserved in the chemosensitive regions near the ventral and dorsal medullary surfaces. These results show that hypoxia-...Continue Reading


Aug 1, 1975·The American Journal of Physiology·S Lahiri
Nov 1, 1978·Journal of Neurochemistry·L Berntman, B Siesjö
Dec 11, 1992·Journal of Applied Physiology·F XuJ W Severinghaus
Jan 1, 1992·The Journal of Physiology·N W DaviesP R Stanfield
Feb 1, 1992·Journal of Applied Physiology·F G Issa, J E Remmers
Jun 1, 1992·Journal of Applied Physiology·Joseph C LamannaR M Farrell
Dec 11, 1991·Journal of Applied Physiology·F D XuJ W Severinghaus
Feb 1, 1990·Journal of Applied Physiology·J A NeubauerN H Edelman
Sep 1, 1987·Metabolic Brain Disease·Joseph C Lamanna
Jun 11, 1969·The American Journal of Physiology·Z Gottesfeld, A T Miller
Nov 1, 1973·Journal of Neurochemistry·U PonténB Siesjö
Nov 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T I MuschN T Bateman
Oct 1, 1984·Analytical Biochemistry·Joseph C Lamanna, K A McCracken
Jan 1, 1981·Reviews of Physiology, Biochemistry and Pharmacology·M E Schlaefke
Jan 15, 1981·Analytical Biochemistry·W D LustJ V Passonneau
Dec 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·C F Cartheuser
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Jiang, G G Haddad
Jul 1, 1993·Journal of Applied Physiology·E L CoatesE E Nattie
Feb 1, 1993·Journal of Applied Physiology·Musa A HaxhiuK P Strohl


Oct 17, 2002·The Journal of Physiology·Olivier PascualJean Champagnat
Oct 12, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li-Ming ChenWalter F Boron
Jun 23, 2009·Journal of Pharmacological Sciences·Saori TsunekawaAkira Haji
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan

Related Concepts

Surface Electromyography
Energy Metabolism
Hydrogen-Ion Concentration
Medulla Oblongata
Oxygen Consumption
Respiratory Failure
Respiratory Mechanics
Tissue Fixation

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.