PMID: 8904598Oct 1, 1996

Decreased energy metabolism in brain stem during central respiratory depression in response to hypoxia

Journal of Applied Physiology
Joseph C LamannaN S Cherniack

Abstract

Metabolic changes in the brain stem were measured at the time when oxygen deprivation-induced respiratory depression occurred. Eucapnic ventilation with 8% oxygen in vagotomized urethan-anesthetized rats resulted in cessation of respiratory drive, monitored by recording diaphragm electromyographic activity, on average within 11 min (range 5-27 min), presumably via central depressant mechanisms. At that time, the brain stems were frozen in situ for metabolic analyses. By using 20-microns lyophilized sections from frozen-fixed brain stem, microregional analyses of ATP, phosphocreatine, lactate, and intracellular pH were made from 1) the ventral portion of the nucleus gigantocellularis and the parapyramidal nucleus; 2) the compact and ventral portions of the nucleus ambiguus; 3) midline neurons; 4) nucleus tractus solitarii; and 5) the spinal trigeminal nucleus. At the time of respiratory depression, lactate was elevated threefold in all regions. Both ATP and phosphocreatine were decreased to 50 and 25% of control, respectively. Intracellular pH was more acidic by 0.2-0.4 unit in these regions but was relatively preserved in the chemosensitive regions near the ventral and dorsal medullary surfaces. These results show that hypoxia-...Continue Reading

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Citations

Oct 17, 2002·The Journal of Physiology·Olivier PascualJean Champagnat
Oct 12, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li-Ming ChenWalter F Boron
Jun 23, 2009·Journal of Pharmacological Sciences·Saori TsunekawaAkira Haji
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan

Related Concepts

Anoxemia
Surface Electromyography
Energy Metabolism
Cytochemistry
Hydrogen-Ion Concentration
Medulla Oblongata
Oxygen Consumption
Respiratory Failure
Respiratory Mechanics
Tissue Fixation

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