Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Xueying ZhaoJohn D Imig

Abstract

Previous studies suggest that epoxyeicosatrienoic acids (EETs) are vasodilators of the mesenteric artery; however, the production and regulation of EETs in the mesenteric artery remain unclear. The present study was designed 1) to determine which epoxygenase isoform may contribute to formation of EETs in mesenteric arteries and 2) to determine the regulation of mesenteric artery cytochrome P-450 (CYP) enzymes in obese Zucker rats. Microvessels were incubated with arachidonic acid, and CYP enzyme activity was determined. Mesenteric arteries demonstrate detectable epoxygenase and hydroxylase activities. Next, protein and mRNA expressions were determined in microvessels. Although renal microvessels express CYP2C23 mRNA and protein, mesenteric arteries lacked CYP2C23 expression. CYP2C11 and CYP2J mRNA and protein were expressed in mesenteric arteries and renal microvessels. In addition, mesenteric artery protein expression was evaluated in lean and obese Zucker rats. Compared with lean Zucker rats, mesenteric arterial CYP2C11 and CYP2J proteins were decreased by 38 and 43%, respectively, in obese Zucker rats. In contrast, soluble epoxide hydrolase mRNA and protein expressions were significantly increased in obese Zucker rat mesente...Continue Reading

References

Jan 1, 1996·The American Journal of Physiology·J D ImigR J Roman
Mar 1, 1996·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·M S Wolin
Nov 1, 1996·Journal of the American Society of Nephrology : JASN·J D ImigJ R Falck
Feb 1, 1997·The American Journal of Physiology·J S Jin, H G Bohlen
Aug 1, 1997·Circulation Research·N L WeintraubA A Spector
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M Guerre-Millo
Jun 11, 1999·The American Journal of Physiology·X NguyenM L Schwartzman
Sep 24, 1999·The Journal of Clinical Investigation·V R HollaJ H Capdevila
Oct 16, 1999·Nature·B FisslthalerR Busse
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Y ZhangM VanRollins
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A HuangG Kaley
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S J WiggH C Parkington
Jul 14, 2001·The Journal of Biological Chemistry·D C Zeldin
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J C Frisbee, D W Stepp
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J C Frisbee
Mar 8, 2002·Hypertension·Jennifer C SullivanJennifer S Pollock
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magdalena Alonso-GaliciaRichard J Roman

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May 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ayala LuriaBruce D Hammock
Aug 26, 2009·The Journal of Biological Chemistry·Eduardo Barbosa-SicardIngrid Fleming
Dec 22, 2011·American Journal of Physiology. Endocrinology and Metabolism·Katherine N ThekenCraig R Lee
Feb 3, 2012·Physiological Reviews·John D Imig
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Angela P H BurgessAttallah Kappas
Sep 1, 2014·Prostaglandins & Other Lipid Mediators·Claudia E RamirezNancy J Brown
Feb 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·John D Imig
Jun 11, 2016·Drug Metabolism Reviews·Michael Murray
Dec 15, 2016·Scientific Reports·Megan E CapozziJohn S Penn
Jul 20, 2016·Prostaglandins & Other Lipid Mediators·Md Abdul Hye KhanJohn D Imig
Nov 12, 2014·The Journal of Physiology·Jefferson C FrisbeePaul D Chantler
May 17, 2006·Clinical and Experimental Pharmacology & Physiology·David W Stepp
Nov 7, 2009·Journal of Molecular and Cellular Cardiology·Yangmei DengCraig R Lee
Jul 17, 2018·Drug Metabolism Reviews·Aneesh A Argikar, Upendra A Argikar
Dec 13, 2006·Hypertension·Kathryn A HagedornSandra T Davidge
Jan 15, 2015·Hypertension·John D Imig
Jan 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Wei ZhouHon-Chi Lee
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Xueying ZhaoJohn D Imig
Mar 4, 2008·Basic & Clinical Pharmacology & Toxicology·Sarbani GhoshSteven L Roberds
Jul 16, 2013·Translational Stroke Research·Catherine M DavisNabil J Alkayed
Jun 13, 2006·Clinical Science·John D Imig
Mar 1, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Clothilde RocheJeremy Bellien
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Shane A Phillips
Feb 7, 2015·British Journal of Clinical Pharmacology·L YangI B Wilkinson
Dec 2, 2015·British Journal of Clinical Pharmacology·Aili L LazaarJoseph Cheriyan
Sep 3, 2019·Physiological Research·J D Imig
Oct 11, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jianan ZhangGuodong Zhang
Dec 8, 2006·Trends in Pharmacological Sciences·Brandon T LarsenDavid D Gutterman
Jul 14, 2021·British Journal of Pharmacology·Md Abdul Hye KhanJohn D Imig
Aug 17, 2021·Frontiers in Physiology·Nathalie Tristão Banhos DelgadoRoger Lyrio Dos Santos

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