Decreased expression and functionality of NMDA receptor complexes persist in the CA1, but not in the dentate gyrus after transient cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
J C HsuJ H Eubanks

Abstract

The authors investigated the gene expression of the NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) receptor and the functional electrophysiologic activity of NMDA receptor complexes in the vulnerable CA1 and less vulnerable dentate gyrus subfields of the rat hippocampus at different times after transient cerebral ischemia. Decreased expression for both subtypes was observed in both the CA1 subfield and dentate granule cell layer at early times after challenge; however, the decreased expression in the dentate granule cell layer was reversible because mRNA levels for both the NR2A and NR2B subtypes recovered to, or surpassed, sham-operated mRNA levels by 3 days postchallenge. No recovery of expression for either subtype was observed in the CA1 subfield. The functional activity of NMDA receptor complexes, as assessed by slow field excitatory postsynaptic potentiations (slow f-EPSP) in CA1 pyramidal neurons, was maintained at 6 hours postchallenge; however, this activity was diminished greatly by 24 hours postchallenge, and absent at 7 days postchallenge. A similar pattern was observed for the non-NMDA receptor-mediated fast f-EPSP. In dentate granule neurons, however, no significant change in NMDA receptor-mediated slow f-E...Continue Reading

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Citations

Mar 26, 2003·Brain Research. Molecular Brain Research·Shiro YamashitaToshifumi Itano
Dec 24, 2008·Neurochemistry International·Severiano Dos-AnjosArsenio Fernández-López
Apr 14, 2010·The European Journal of Neuroscience·Ibrahim A AlhaiderKarim A Alkadhi
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Feb 9, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nidia QuillinanPaco S Herson
Apr 10, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D WigleM C Wallace
Nov 8, 2003·Stroke; a Journal of Cerebral Circulation·Xiangning JiangDonna M Ferriero
May 21, 2019·Frontiers in Cellular Neuroscience·Yongjun SunZibin Gao

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