Decreased expression of aquaporin water channels in denervated rat kidney

Nephron. Physiology
JongUn LeeKi Chul Choi

Abstract

A neural mechanism regulating aquaporin (AQP) water channels in the kidney was investigated. Male Sprague-Dawley rats were used. Renal denervation was induced by painting the renal vessels with 10% phenol. The expression of AQP1-4 proteins was determined in the denervated and contralateral kidneys. The expression was also examined in rats which were renally denervated and subjected to water restriction or deoxycorticosterone acetate (DOCA)-salt treatment. Following the unilateral denervation, tissue contents of norepinephrine were significantly decreased in the denervated kidney, while increased in the contralateral kidney. Accordingly, the expression of AQP1-4 proteins was decreased by 15-40% in the denervated kidney, and increased by 30-50% in the contralateral kidney. Immunohistochemistry of AQP2 confirmed its decreases in the denervated kidney and increases in the contralateral kidney. In bilaterally denervated rats, the urine flow increased along with decreased osmolarity. The water restriction increased the expression of AQP channels, however, the magnitude of which was lower in the denervated than in the contralateral kidney. Renal denervation decreased the degree of DOCA-salt hypertension, along with lower expression of...Continue Reading

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Citations

Mar 18, 2015·British Journal of Clinical Pharmacology·Frank H MoseErling B Pedersen
Jan 13, 2012·Acta Oto-laryngologica·Mona El-Rabie AhmedYasuo Hisa
Mar 6, 2010·European Journal of Endocrinology·Thomas G LauridsenErling B Pedersen
Dec 1, 2009·Electrolyte & Blood Pressure : E & BP·Eun Hui Bae, Seong Kwon Ma
Jun 1, 2008·Electrolyte & Blood Pressure : E & BP·Jongun Lee
Aug 30, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Henrik VaseErling Bjerregaard Pedersen
Feb 7, 2015·American Journal of Physiology. Renal Physiology·Carol M Herak-KrambergerIvan Sabolić
Aug 7, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ahmad AzlinaKazuo Hosoi
May 3, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xuefei LiKazuo Hosoi
Jan 12, 2021·American Journal of Physiology. Renal Physiology·Mengke HanChunling Li

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