Decreased expression of B7 costimulatory molecules and major histocompatibility complex class-I in human hepatocellular carcinoma

Journal of Gastroenterology and Hepatology
Keishi FujiwaraYasushi Shiratori

Abstract

We analyzed the expression of antigen-processing and antigen-presenting molecules in surgically resected fresh samples of human hepatocellular carcinoma (HCC) tissue to elucidate a mechanism of immune escape. We also examined the expression of interleukin (IL)-10 protein, which might act to downregulate expression of antigen-processing and antigen-presenting molecules. Twenty-eight HCC samples obtained by surgical resection were analyzed for the expression of beta2-microglobulin, heat-shock protein (HSP)-70, human leukocyte antigen (HLA) class-I, CD80 (B7-1), CD86 (B7-2) and IL-10 by immunostaining. Beta2-microglobulin and HSP-70 were preserved in all samples. In contrast, the expression of HLA class-I molecules was significantly reduced according to lowering in the histological grading of tumor differentiation (P = 0.024). Furthermore, B7-1 and B7-2 expression was reduced in tumor cells compared with corresponding areas of liver tissue without malignant involvement irrespective of the histological grading of tumors (21% and 36%, respectively). Although IL-10 protein was expressed in 54% of HCC, no relationship between the expression of IL-10 and downregulation of B7-1, B7-2, and HLA class-I was evident. These findings suggest ...Continue Reading

References

May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Okuda
Dec 15, 1990·International Journal of Cancer. Journal International Du Cancer·M E Connor, P L Stern
Apr 1, 1988·British Journal of Cancer·A C PatersonV J Desmet
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·R S McHughP Selvaraj
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN International Working Party
Mar 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D YoungW Born
Jun 9, 1995·International Journal of Cancer. Journal International Du Cancer·Q WangR M Bukowski
Aug 1, 1994·Clinical and Experimental Immunology·A A WadeeS G Reddy
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R AngusM O Symes
Aug 12, 1993·Annals of the New York Academy of Sciences·W F BodmerJ G Bodmer
Apr 17, 1996·Journal of the National Cancer Institute·N KunduA M Fulton
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MiyagawaM Makuuchi
May 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TatsumiN Hayashi
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y WadaM Kojiro
Feb 3, 1999·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·E JägerA Knuth
Aug 24, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S HuangM Bar-Eli
Nov 27, 1999·British Journal of Cancer·K KariyamaT Tsuji
Apr 13, 2000·International Journal of Cancer. Journal International Du Cancer·A MackensenA Lindemann

❮ Previous
Next ❯

Citations

Jun 8, 2012·Cancer Immunology, Immunotherapy : CII·Miriam AlbDavid Schrama
Mar 28, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E Ortiz-SánchezE Garrido
Mar 11, 2009·Journal of Biomedical Science·Pablo MatarGuillermo Mazzolini
Jul 28, 2005·Journal of Inflammation·Jennifer M RyanBernard P Mahon
Dec 18, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Bei ZhongXiang Gao
Aug 5, 2014·BioMed Research International·Gaetano BertinoIsidoro Di Carlo
Jun 22, 2010·Journal of Cancer Research and Clinical Oncology·Guoqiang LiXuehao Wang
Nov 6, 2015·Cancer·James J HardingGhassan K Abou-Alfa
Nov 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert ThimmeHans Christian Spangenberg
Mar 22, 2016·Cellular & Molecular Immunology·Zongwen ShuaiM Eric Gershwin
Dec 15, 2010·Journal of Hepatology·Ekaterina Breous, Robert Thimme
Mar 4, 2015·Journal of Hepatology·Oxana V Makarova-RusherTim F Greten
Oct 31, 2012·Digestive Diseases·Nathalie SchmidtRobert Thimme
Oct 1, 2015·World Journal of Gastroenterology : WJG·Nobuhiro TsuchiyaTetsuya Nakatsura
May 23, 2018·Journal of Immunology Research·Yingjun XieXuewen Zhang
May 31, 2018·Journal of Experimental & Clinical Cancer Research : CR·Feng XuChaoliu Dai
Apr 22, 2015·BioMed Research International·Gaetano BertinoMichele Malaguarnera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.