PMID: 9523577Apr 2, 1998Paper

Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures

Journal of Neurochemistry
C SolàJ Serratosa

Abstract

The Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the phosphatase calcineurin (CaN) are especially abundant in the mammalian CNS, where they have been implicated repeatedly in different neuronal functions. CaMKII is a holoenzyme that is likely to be constituted of both homomultimers and heteromultimers, CaMKIIalpha and CaMKIIbeta being the most abundant subunits in the brain. CaN is a heterodimer constituted of a catalytic subunit (CaN A) and a regulatory subunit (CaN B), and CaN Aalpha is the predominant form in the brain. We studied the expression of CaMKIIalpha, CaMKIIbeta, and CaN Aalpha subunit messenger RNAs in the mouse hippocampus at different times after the administration of a convulsant dose of kainic acid. CaMKIIalpha and CaN A immunohistochemistry was also performed. We observed a transient decrease in the three messenger RNAs in the kainic acid-treated mice, peaking at 5 or 24 h of treatment. The effect had disappeared completely 8 days after treatment. No significant alterations in CaMKII or CaN immunolabelling were observed in the hippocampus of kainic acid-treated mice. The observed modifications could be due to the neuronal hyperexcitability induced by kainic acid rather than neuronal degeneration, ...Continue Reading

Citations

Aug 28, 2020·The Journal of Physiology·Kotaro HoriMurali Prakriya
May 17, 2008·CNS Neuroscience & Therapeutics·Germán Sierra-Paredes, Germán Sierra-Marcuño
May 2, 2001·The International Journal of Biochemistry & Cell Biology·C SolàJ Serratosa
Apr 1, 2000·Journal of Neuroimmunology·P Mukherjee, G M Pasinetti

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