PMID: 9422546Jan 9, 1998Paper

Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature

The American Journal of Pathology
H NishiyamaJ Fujita

Abstract

Physiological scrotal hypothermia is necessary for normal spermatogenesis and fertility in mammals. Cirp is a recently identified cold-inducible RNA-binding protein that is inducible at 32 degrees C in mouse somatic cells in vitro. Cirp is constitutively expressed in the testis of mouse and structurally highly similar to RBM1, a candidate for the human azoospermia factor. To elucidate the role played by Cirp in spermatogenesis, we investigated its expression levels during spermatogenesis and after heat stress. In the mouse testis, cirp mRNA was detected in the germ cells, and the level varied depending on the stage of differentiation. Also, a high level of Cirp protein was detected immunohistochemically in the nucleus of primary spermatocytes. Expression of Cirp was decreased in the GC-2spd(ts) mouse germ cell line when culture temperature was raised from 32 degrees C to 37 degrees C. When mouse testis was exposed to heat stress by experimental cryptorchidism or immersion of the lower abdomen in warm (42 degrees C) water, the expression of Cirp was decreased in the testis within 6 hours after either treatment. In human testis with varicocele analyzed immunohistochemically, germ cells expressed less Cirp protein than those in th...Continue Reading

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Citations

Dec 3, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·B Schaller, R Graf
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tomoko MasudaJun Fujita
Nov 30, 2000·Nucleic Acids Research·K MatsumotoM Tsujimoto
Jul 1, 2011·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Michael L Eisenberg, Larry I Lipshultz

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