Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma

International Journal of Cancer. Journal International Du Cancer
Jenny C HoSheung Tat Fan

Abstract

Cytochrome P450-2E1 (CYP2E1) is one of the major hepatic enzymes involved in the metabolism of procarcinogen. Our study aimed to investigate the differential expression level of CYP2E1 and its clinicopathological significance in hepatocellular carcinoma (HCC). CYP2E1 revealed low level of expression in 70% of the tumor tissues, when compared to the adjacent nontumor tissues, at both mRNA and protein levels. The low expression of CYP2E1 was significantly correlated with the aggressive tumor phenotype, including poor differentiation status (by the Edmondson grading system) (p=0.038), absence of tumor capsule (p=0.030) and younger age of the patients (p=0.002). Multivariate analysis indicated that CYP2E1 expression level and pTNM stage were independent prognostic factors for disease-free survival. CYP2E1 was also shown to have a differential expression level in different liver tissues. The level of CYP2E1 was significantly higher in nontumor tissues from HCC patients compared to the intermediate level in cirrhosis livers from noncancer patients and normal livers from healthy persons. Tumor tissues were shown to have the lowest expression level. In conclusion, our results have shown that CYP2E1 is upregulated in the nontumor tissue...Continue Reading

References

Feb 14, 1992·Archives of Biochemistry and Biophysics·D J TierneyD R Koop
Jan 6, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D R Koop
Mar 1, 1991·Chemical Research in Toxicology·F P GuengerichM Iwasaki
Jan 1, 1991·Methods in Enzymology·C S YangJ S Yoo
Jan 1, 1988·Molecular Aspects of Medicine·T J Peters, R J Ward
Aug 1, 1987·Molecular Endocrinology·B J SongF J Gonzalez
Feb 13, 1987·Biochemical and Biophysical Research Communications·J Y HongC S Yang
Sep 27, 1996·The Journal of Biological Chemistry·D Wu, A I Cederbaum
Apr 11, 1997·The Journal of Biological Chemistry·B J Roberts
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·H S LeeC Y Kim
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M D WeltmanC Liddle
Feb 7, 1998·Journal of Hepatology·K DilgerU Klotz
Apr 29, 1998·Clinical Pharmacology and Therapeutics·G J BurckartR Venkataramanan
May 9, 1998·Molecular Pharmacology·Q Chen, A I Cederbaum
Nov 20, 1998·The American Journal of Gastroenterology·V M MishinC S Lieber
Feb 24, 2000·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·I DupontD Lucas
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Marí, A I Cederbaum
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kimberley J WoodcroftRaymond F Novak
Jun 12, 2002·Molecular Biology of the Cell·Xin ChenPatrick O Brown
Jun 18, 2002·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yoichiro HiroseYuichi Sugisaki
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kengathevy MorganTimothy R Morgan
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Moritoshi Kinoshita, Masahiko Miyata
Sep 19, 2002·The Journal of International Medical Research·S TakahashiM Hirakawa

❮ Previous
Next ❯

Citations

Jan 29, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nicholas S LukeHisham A El-Masri
Aug 1, 2007·Biomarkers in Medicine·Nikki P Y LeeJohn M Luk
Apr 21, 2010·Experimental Biology and Medicine·Hui YangYu-Jui Yvonne Wan
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jenny C HoSheung Tat Fan
Jun 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi Shi, Aimin Huang
Feb 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jen-Tai LinYow-Ling Shiue
Jul 22, 2019·The International Journal of Occupational and Environmental Medicine·Aisha Mohamed SamirHany Ahmed Fouad Alghobary
Mar 25, 2017·International Journal of Oncology·Lu LiYanyan Liu
Apr 28, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Grażyna Kubiak-TomaszewskaGrażyna Nowicka
Jan 25, 2020·Molecular Medicine Reports·Rui-Ying WangXiao-Bing Shen
Jul 1, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jiaqi WangSu Zeng
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Chakkaphan KhenjantaPuangrat Yongvanit
Jun 27, 2014·Journal of Proteome Research·Masato TaokaTadashi Kondo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.