Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance

Diabetes
Istvan KuruczL Korányi

Abstract

Oxidative stress has been ascribed a role in the pathogenesis of diabetes and its complications, and stress proteins have been shown to protect organisms in vitro and in vivo against oxidative stress. To study the putative role of one of the most abundant cytoprotective stress proteins, inducible cytoplasmic 72-kDa-mass heat shock protein (Hsp-72), in the pathogenesis of diabetes, we measured its mRNA concentration in muscle biopsies from six type 2 diabetic patients and six healthy control subjects (protocol 1) as well as in 12 twin pairs discordant for type 2 diabetes and 12 control subjects undergoing a euglycemic-hyperinsulinemic clamp in combination with indirect calorimetry (protocol 2). The amount of Hsp-72 mRNA in muscle was significantly lower in type 2 diabetic patients than in healthy control subjects (in protocol 1: 5.2 +/- 2.2 vs. 53 +/- 32 million copies of Hsp-72 mRNA/microg total RNA, n = 6, P = 0.0039; in protocol 2: 3.2 +/- 3.3 vs. 43 +/- 31 million copies of Hsp-72 mRNA/microg total RNA, n = 12, P = 0.0001). Hsp-72 mRNA levels were also markedly reduced in the nondiabetic co-twins compared with healthy control subjects (5.8 +/- 5.0 vs. 43 +/- 31, n = 12, P = 0.0001), but they were also statistically significa...Continue Reading

References

Jan 1, 1990·Immunogenetics·C M Milner, R D Campbell
Jan 2, 1992·Nature·M J Gething, J Sambrook
Dec 15, 1988·Biochemical and Biophysical Research Communications·Y DeguchiS Kishimoto
Apr 1, 1985·The American Journal of Clinical Nutrition·H C LukaskiG I Lykken
Nov 30, 1994·Experientia·E Günther, L Walter
Nov 1, 1995·Trends in Biochemical Sciences·P J ThomasP L Pedersen
Feb 15, 1996·The Journal of Clinical Investigation·M SaghizadehP A Kern
Jan 1, 1995·Annual Review of Cell and Developmental Biology·C Wu
Mar 1, 1996·The American Journal of Physiology·J M MatzM J Blake
Mar 1, 1997·Electrophoresis·L Anderson, J Seilhamer
May 15, 1998·Nature·G García-CardeñaW C Sessa
Aug 1, 1998·Circulation Research·I J Benjamin, D R McMillan
Jan 23, 1999·The Journal of Biological Chemistry·J E PessinS Okada
Jan 26, 1999·Critical Reviews in Biochemistry and Molecular Biology·T YlikomiH Gronemeyer
Feb 18, 1999·Molecular and Cellular Biology·S P GygiR Aebersold
Apr 30, 1999·Physiological Reviews·A L Fink
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·J MuchováZ Duracková
Mar 29, 2000·Seminars in Cell & Developmental Biology·V R Agashe, F U Hartl
Jul 27, 2000·Medicine and Science in Sports and Exercise·A AlbrightL S Verity

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Citations

Nov 25, 2005·European Journal of Nutrition·I Rosier Olimpio Pereira, D Saes Parra Abdalla
Oct 10, 2008·Cell Stress & Chaperones·K KavanaghJanice D Wagner
Jan 18, 2013·Cell Stress & Chaperones·Shirlee JaffeSteven S Witkin
Jan 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jason ChungMark A Febbraio
Mar 2, 2005·Diabetes Technology & Therapeutics·Philip L Hooper, Joanna J Hooper
Mar 10, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kylie KavanaghStephen B Kritchevsky
Nov 23, 2010·Exercise and Sport Sciences Reviews·Paige C Geiger, Anisha A Gupte
Sep 8, 2012·Genome Research·Alexandra E CharosMichael Snyder
Feb 18, 2011·American Journal of Physiology. Endocrinology and Metabolism·Kylie KavanaghJanice D Wagner
Dec 15, 2010·Journal of Applied Physiology·Anisha A GuptePaige C Geiger
Jan 31, 2008·Cell Stress & Chaperones·Vittorio CalabresePietro Castellino
Jul 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Ferah ArmutcuAhmet Gurel
May 28, 2013·The Journal of Endocrinology·Karen OlivaMartha Lappas
Oct 30, 2009·International Journal of Molecular Sciences·Carla M SáCristina Pereira-Wilson
Jan 7, 2014·Metabolic Syndrome and Related Disorders·Botond Literáti-NagyZoltán Szilvássy
Oct 19, 2011·Experimental Diabetes Research·Saeid GolbidiIsmail Laher
Aug 27, 2013·Cell Stress & Chaperones·Mariana Aguiar de MatosFabiano Trigueiro Amorim
Feb 14, 2014·Cell Stress & Chaperones·Philip L HooperLaszlo Vigh
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mary Elizabeth PattiLawrence J Mandarino
Jun 1, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Philip Newsholme, Paulo I Homem de Bittencourt
Nov 10, 2009·Bioscience, Biotechnology, and Biochemistry·Hirohumi InoueYuji Yamamoto
May 13, 2014·Diabetologia·Stéphane Jaisson, Philippe Gillery
Jan 5, 2012·Cell Stress & Chaperones·Josianne Rodrigues-KrauseGerard Colleran
Mar 6, 2013·Current Cardiovascular Risk Reports·Vicencia Sales, Mary-Elizabeth Patti
Sep 9, 2006·Respiration; International Review of Thoracic Diseases·Do Jin KimSeung Kyoon Woo
Aug 17, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S Zahra BathaieManouchehr Nakhjavani
Dec 22, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hirofumi KaiEiichi Araki
Jul 17, 2012·Expert Opinion on Therapeutic Targets·Chantal KeijzerFemke Broere
Aug 18, 2009·Expert Review of Proteomics·Belén PeralJuan Antonio López
Sep 4, 2015·Molecular Nutrition & Food Research·Vasso ApostolopoulosBarbora de Courten
May 25, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ann M Petersen, Todd T Gleeson
Jul 27, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Ramanna Valmiki RajeshHyun-Jeong Lee
Mar 5, 2010·Metabolism: Clinical and Experimental·Darren C HenstridgeBarbora de Courten
Apr 1, 2010·Obesity Research & Clinical Practice·Tatsuya KondoEiichi Araki
Jul 7, 2009·Diabetes Research and Clinical Practice·T ImatohH Une

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