Decreased expression of long non-coding RNA LOC728290 in human hepatocellular carcinoma

Oncology Letters
Shaogeng ZhangPeng-Hui Yang

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality worldwide. Despite progress in the diagnosis and treatment of HCC, prognosis remains unfavorable. Long non-coding RNAs (lncRNAs) are emerging as important factors in tumorigenesis and cancer progression; however, the underlying molecular mechanisms and clinical significance of lncRNAs in HCC remain largely unknown. The present study examined the expression pattern and clinical significance of a novel lncRNA, LOC728290, in HCC. Expression of LOC728290 was markedly decreased in HCC tissues compared with adjacent non-tumor liver tissues, as detected using the reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The area under the receiver operating characteristic curve for LOC728290 was 0.728. The expression of LOC728290 was associated with the level of α-fetoprotein and microvascular invasion. Furthermore, patients with low LOC728290 expression exhibited decreased recurrence-free survival times (P<0.05) compared with those with high LOC728290 expression. The results of the present study indicated that downregulation of LOC728290 in patients with HCC may be a powerful tumor biomarker, with potential clinical applications in prognosi...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Jan 6, 2012·The New England Journal of Medicine·James J Yeh, Marc Uemura
Jan 6, 2012·The New England Journal of Medicine·Emmanuel A TsochatzisAndrew K Burroughs
Oct 17, 2012·CA: a Cancer Journal for Clinicians·Mary Maluccio, Anne Covey
Mar 7, 2013·Genetics·Johnny T Y KungJeannie T Lee
Mar 14, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dan XuShu-han Sun
Feb 15, 2014·The International Journal of Biological Markers·Brian I CarrUNKNOWN Italian Liver Cancer Group
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fang WangShu-Han Sun
Sep 10, 2014·Nature Reviews. Cardiology·Thomas Thum
Oct 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stefan OhrnbergerAlfred Nordheim
Oct 22, 2015·Journal of Gastroenterology and Hepatology·Ben YueDongwang Yan

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Citations

Mar 3, 2018·International Journal of Molecular Sciences·Manuela LanzafameSalvatore Piscuoglio
Jun 20, 2020·Scientific Reports·Adriana Camargo FerrasiMaria Inês de Moura Campos Pardini

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Datasets Mentioned

BETA
GSE55191
GSE5804

Software Mentioned

SPSS

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