Decreased expression of MMP-9 in CD8(+) cells in placenta with severe preeclampsia

Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
M OrlovicV Soljic

Abstract

We compared the number of CD4-positive (CD4(+)) and CD8-positive (CD8(+)) cells in severe and non-severe preeclampsia (PE), and in normal pregnancy. We also evaluated the expression of matrix metalloproteinase 9 (MMP-9) in CD4(+) and CD8(+) cells. Immunohistochemistry for CD4(+) and CD8(+) was performed on the decidua basalis of 15 severe and 13 non-severe PE women and compared to decidual tissue of 19 normal pregnancies (control group). Co-expression of MMP-9 with CD8(+) and CD4(+) cells was determined by double immunofluorescence staining. The median number of CD8(+) cells/mm(2) was significantly lower for the severe PE group than for the normal pregnancy group, as was the number of CD4(+) cells and MMP-9(+)CD8(+) cells. No statistical difference was found between the non-severe PE group and the normal pregnancy group. The significant decrease of CD4(+), CD8(+) and MMP-9(+)CD8(+) cells at the fetal-maternal interface only in the severe PE group suggests that immunological disorders play a role in the pathophysiology of severe PE.

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Citations

Oct 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Salema Jafri, Mark L Ormiston

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