Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy

Epilepsia
Erwin A van VlietJan A Gorter

Abstract

We previously showed that gene expression of synaptic vesicle protein 2A (SV2A), the binding site for the antiepileptic drug levetiracetam, is reduced during epileptogenesis in the rat. Since absence of SV2A has been associated with increased epileptogenicity, changes in expression of SV2A could have consequences for the progression of epilepsy. Therefore we investigated hippocampal SV2A protein expression of temporal lobe epilepsy (TLE) patients and in rats during epileptogenesis and in the chronic epileptic phase. SV2A immunocytochemistry and Western blot analysis were performed on the hippocampus of autopsy controls, patients that died from status epilepticus (SE), and pharmacoresistant TLE patients. In addition, in epileptic rats, SV2A expression was determined after SE during the acute, latent, and chronic epileptic phase. In control tissue, presynaptic SV2A was expressed in all hippocampal subfields, with strongest expression in mossy fiber terminals. SV2A positive puncta were distributed in a patchy pattern over the somata and dendrites of neurons. SV2A decreased throughout the hippocampus of TLE patients with hippocampal sclerosis (HS), compared to autopsy control, SE, and non-HS tissue. In most rats, SV2A was already d...Continue Reading

References

Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S M BajjaliehR H Scheller
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·K M CrowderS M Bajjalieh
Aug 3, 2001·Nature Cell Biology·T Xu, S M Bajjalieh
Feb 11, 2003·Epilepsy Research·Elinor Ben-MenachemBernd Schmidt
Oct 14, 2003·European Journal of Pharmacology·Michel GillardPierre Chatelain
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Berkley A LynchBruno Fuks
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kenneth L CusterSandra M Bajjalieh
Mar 1, 2006·Neurology·Daniel Friedman, Jacqueline A French
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan A GorterWytse J Wadman
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Philipp von Rosenstiel
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Barbara BennettNathalie Toublanc
Feb 13, 2008·Epilepsia·Erwin A van VlietJan A Gorter

❮ Previous
Next ❯

Citations

Nov 10, 2012·Pediatric Research·Delia M TalosFrances E Jensen
Jun 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jonathan E CohenR Douglas Fields
Mar 17, 2010·Epilepsy Currents·Graeme J Sills
Jan 6, 2012·PloS One·Amy NowackSandra M Bajjalieh
Mar 6, 2013·Neuropsychiatric Disease and Treatment·Justine Cormier, Catherine J Chu
Feb 4, 2010·Current Opinion in Neurology·Carl E Stafstrom
Sep 4, 2015·Expert Opinion on Pharmacotherapy·Caterina PalleriaEmilio Russo
Dec 23, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gaetano Zaccara, Dieter Schmidt
Apr 7, 2015·Journal of Neuroscience Methods·Jan A GorterFernando H Lopes da Silva
Dec 19, 2012·Epilepsia·Pablo M Casillas-EspinosaTerence J O'Brien
Oct 10, 2013·The European Journal of Neuroscience·Julieta Griselda Mendoza-TorreblancaGisela Gómez-Lira
Nov 26, 2010·Seizure : the Journal of the British Epilepsy Association·S DedeurwaerdereT J O'Brien
Oct 26, 2016·CNS Drugs·Wolfgang LöscherHenrik Klitgaard
Jun 27, 2017·Molecular Pharmaceutics·Guillaume BeckerAlain Plenevaux
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Elisa SerranoAlain Plenevaux
Mar 8, 2017·Pharmacological Reviews·Ying C Li, Ege T Kavalali
Oct 2, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Samantha RossanoRichard E Carson
Nov 22, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Maria Elisa SerranoAlain Plenevaux
Mar 25, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Maria Elisa SerranoAlain Plenevaux
Aug 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sjoerd J FinnemaRichard E Carson
Aug 23, 2017·Expert Opinion on Drug Discovery·Emilio RussoMarco Mula
Dec 12, 2018·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kentaro TokudomeYukihiro Ohno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.