Decreased expression of T-cell costimulatory molecule CD28 on CD4 and CD8 T cells of mexican patients with pulmonary tuberculosis.

Tuberculosis Research and Treatment
German Bernal-FernandezRaul Mancilla

Abstract

Patients with tuberculosis frequently develop anergy, a state of T-cell hyporesponsiveness in which defective T-cell costimulation could be a factor. To know if the expression of T-cell costimulatory molecules was altered in tuberculosis, we analyzed the peripheral blood T-cell phenotype of 23 Mexican patients with pulmonary tuberculosis. There was severe CD4 (P < .001) and CD8 (P < .01) lymphopenia and upregulation of costimulatory molecule CD30 on CD4 and CD8 T cells (P < .05); this increase was higher in relapsing tuberculosis. The main finding was severe downregulation of the major costimulatory molecule CD28 on both CD8 and CD4 T cells (P < .001). Depletion of the CD4/CD28 subset, a hitherto undescribed finding, is relevant because CD4 T cells constitute the main arm of the cell-mediated antimycobacterial immune response.

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Citations

Jun 30, 2011·Immunology·Marius StriogaDainius Characiejus
Oct 24, 2012·Biochimica Et Biophysica Acta·Devin MorrisVishwanath Venketaraman
Feb 22, 2017·Journal of Clinical Laboratory Analysis·Jun-Chi XuPing Xu

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Methods Mentioned

BETA
flow cytometry
flow
bronchoalveolar lavage

Software Mentioned

Graph Pad Prism
Graph Pad
CellQuest

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