PMID: 2501064Mar 1, 1989Paper

Decreased fibrinolytic capacity and increased von Willebrand factor levels as indicators of endothelial cell dysfunction in patients with lupus anticoagulant

Clinical Rheumatology
T K Nilsson, E Löfvenberg

Abstract

Over a 6-year period, 10 patients with lupus anticoagulant activity were seen. A history of thrombotic disease was found in 6 patients, but only 3 had systemic autoimmune disease. Reduced fibrinolytic activity after venous occlusion was found in 9 subjects, but only 4 had high von Willebrand factor levels. These changes were unrelated to inflammatory activity, which was ruled out by normal serum protein electrophoresis in all but one case. Human brain thromboplastin dilution test was pathological in all subjects with depressed fibrinolytic activity. These two tests may prove to be of value to single out those LA patients with highest risk for development of thromboembolic disease.

References

Dec 15, 1987·Thrombosis Research·T K Nilsson, O Johnson
Jul 1, 1985·American Journal of Hematology·D A GastineauE J Bowie
Jan 24, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·B WimanM Rånby
Mar 1, 1984·The Journal of Clinical Investigation·D B CinesR J DeHoratius

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Citations

Nov 14, 1997·Journal of the American College of Cardiology·S YazdaniL E Rabbani
Jan 1, 1991·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·N Futrell, C H Millikan
Jan 1, 1991·Eye·M Pandolfi, A al-Rushood

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