Decreased follicular phase gonadotropin secretion is associated with impaired estradiol and progesterone secretion during the follicular and luteal phases in normally menstruating women

The Journal of Clinical Endocrinology and Metabolism
U SchweigerK M Pirke

Abstract

We tested the hypothesis that disturbed follicular development and disturbed luteal progesterone (P4) secretion are associated with reduced gonadotropin secretion in the early follicular phase by measuring pulsatile LH and FSH secretion at that time in 53 normally menstruating women. Three groups of women were identified on the basis of serum sex steroid concentrations (measured daily throughout the cycle) and luteal phase length. Group A (n = 27) had normal ovarian hormone secretion with peak serum estradiol (E2) concentrations of 440 pmol/L or more, peak serum P4 concentrations of 19 nmol/L or more, and luteal phase length of 9 days or more. Group B (n = 16) had normal peak serum E2 values, but peak serum P4 values less than 19 nmol/L and/or luteal phase length less than 9 days. Group C (n = 10) had peak serum E2 values below 440 pmol/L. Risk factors for the disturbances found in groups B and C were exercise and/or intermittent dieting. Compared to group A, both groups B and C had reduced mean serum LH concentrations (3.1 +/- 1.5 vs. 2.3 +/- 1.4 and 2.0 +/- 1.0 IU/L; P less than 0.05) and reduced LH pulse frequencies (5.2 +/- 2.1 vs. 3.5 +/- 1.8 and 3.3 +/- 2.3 pulses/12 h; P less than 0.02). LH amplitude was similar in all 3...Continue Reading

Citations

Sep 16, 2003·Medicine and Science in Sports and Exercise·Mary Jane De Souza
Jul 24, 2012·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Nov 20, 2004·Obstetrics and Gynecology Clinics of North America·Orhan Bukulmez, Aydin Arici
Feb 16, 2015·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Jul 1, 1996·Medicine and Science in Sports and Exercise·K M WintersB L Lasley
Jul 23, 1999·Medicine and Science in Sports and Exercise·N I WilliamsB A Turnbull
Apr 9, 2021·Fertility and Sterility·UNKNOWN Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Inf

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