Decreased forebrain [35S]TBPS binding and increased [3H]muscimol binding in rats that do not develop stress-induced behavioral depression

Brain Research
Robert C DruganJ N Crawley

Abstract

Recent evidence suggests that anxiety and its biological concomitants may be involved in the pathophysiology of depression. In the present study, the in vitro radioligand binding of [3H]flunitrazepam, [3H]muscimol and [35S]t-butylbicyclophosphorothionate (TBPS) sites on the benzodiazepine/GABA chloride ionophore receptor complex (BGRC) was examined using the learned helplessness paradigm. Only rats which did not develop the syndrome showed a significant increase in [3H]muscimol binding in cerebral cortex and a decrease in [35S]TBPS binding in cerebral cortex and hippocampus in comparison to naive controls. For both ligands, this represented a change in Bmax rather than a change in affinity. Adrenalectomy had no impact on these alterations indicating that critical endogenous factors are not manufactured by the adrenal glands. These findings suggest that the BGRC in the forebrain may be a site mediating the 'coping' ability of rats that do not develop the learned helplessness syndrome. The possible involvement of neurosteroids in this effect is discussed.

References

May 5, 2001·Physiology & Behavior·R J BlanchardD C Blanchard
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·M AustinRobert C Drugan
Sep 23, 2000·Neuroscience Research·M L KramF Petty
Aug 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·B J CaldaroneR A Rossellini
Oct 16, 2001·Biological Psychology·J A JenkinsF Petty
Mar 24, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Cheryl A FryeMadeline E Rhodes
Nov 29, 2005·Brain, Behavior, and Immunity·Elizabeth A LevayStephen Kent
Dec 17, 2009·Journal of Neurochemistry·Kelly J SkilbeckTina Hinton
Nov 23, 2006·Depression and Anxiety·Allan V Kalueff, David J Nutt
Jan 23, 2008·Genetical Research·Y B SaabA D J Overall

Citations

Dec 1, 1978·Pharmacology, Biochemistry, and Behavior·A S LippaB Beer
Aug 3, 1979·Science·L S Sklar, H Anisman
May 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H PurdyS M Paul
Aug 27, 1986·Brain Research·E B De SouzaM J Kuhar
Oct 1, 1972·Journal of Comparative and Physiological Psychology·S F MaierD A Lieberman
Jul 1, 1970·Journal of Comparative and Physiological Psychology·J M WeissN Harrell
May 1, 1967·Journal of Experimental Psychology·M E Seligman, S F Maier
Jan 18, 1980·Science·J F TallmanD W Gallager
Jul 1, 1980·Neuroscience Letters·M Willow, G A Johnston
Apr 23, 1982·Science·M A VisintainerM E Seligman

Related Concepts

Trichohepatoenteric Syndrome
Neurosteroids
Bicyclo Compounds
Mental Suffering
Benzodiazepine [EPC]
Helplessness, Learned
Learning Disorders
Genus Hippocampus
Structure of Hippocampal Formation
Entire Hippocampus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.