Decreased free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) levels in women with decreased libido

Journal of Sex & Marital Therapy
A T Guay, Jerilynn Jacobson

Abstract

A prior study has shown that premenopausal women could have decreased testosterone levels and still have regular menstrual cycles (Guay, 2001). Since ovarian function in such women was normal, the question of a possible adrenal dysfunction causing androgen deficiency was considered. If this was true, the question then arose as to whether the same defect could be seen in postmenopausal women. We studied 105 women who presented during a 6-month period of time with the chief complaint of decreased sexual desire. On subsequent testing, 74 of the women (70%) were found to have decreased total testosterone, free testosterone, and dehydroepiandrosterone sulfate (DHEA-S). Thirty-six of these women were premenopausal (ages range 24-50 years), and 38 were postmenopausal (ages range 47-78 years). All androgen levels for the women were lower than age-matched control groups found in the literature. The decreased DHEA-S levels suggest a a defect in adrenal steroidogenesis, which was seen in both premenopausal and postmenopausal women. Possible defects in regulatory mechanisms of adrenal steroidogenesis are discussed.

References

Jan 1, 1991·Acta Obstetricia Et Gynecologica Scandinavica·L AnttilaH L Kaihola
Aug 12, 1998·Maturitas·S L Ala-FossiR Punnonen

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Citations

Nov 2, 2007·International Urogynecology Journal and Pelvic Floor Dysfunction·Erdogan Aslan, Michelle Fynes
Mar 31, 2005·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Laurie HeatheringtonLeslie Greenberg
Apr 22, 2005·Journal of Sex & Marital Therapy·A NyuntD E Price
Mar 17, 2004·Menopause : the Journal of the North American Menopause Society·Clarisa R GraciaDeborah B Nelson
Mar 31, 2006·Obstetrical & Gynecological Survey·Rachel N PaulsMickey M Karram
May 14, 2009·Menopause : the Journal of the North American Menopause Society·Fernand LabrieJohn Balser
Mar 24, 2005·Treatments in Endocrinology·Deborah R Cameron, Glenn D Braunstein
Jan 27, 2004·Medicinski pregled·Artur BjelicaMilana Maticki-Sekulić
Feb 9, 2012·Postgraduate Medicine·Martin MinerJohn E Buster
Jul 27, 2007·The Journal of Sexual Medicine·Bulent ErolAtes Kadioglu
Apr 7, 2005·International Journal of Andrology·Ion G Motofei, David L Rowland
Jan 9, 2015·Obstetrics and Gynecology·Sheryl A Kingsberg, Terri Woodard
Oct 27, 2004·Endocrinology and Metabolism Clinics of North America·Clarisa R Gracia, Ellen W Freeman
Apr 3, 2007·Obstetrics and Gynecology·Clarisa R GraciaMarjori Mogul
Dec 18, 2018·Climacteric : the Journal of the International Menopause Society·D J PortmanR Kagan
Dec 14, 2004·International Journal of Impotence Research·B TurnaO Nazli
Mar 28, 2012·The Journal of Medical Investigation : JMI·Toshiyuki YasuiMinoru Irahara
Oct 26, 2018·Menopause : the Journal of the North American Menopause Society·Clarisa R GraciaDeborah B Nelson
Apr 1, 2016·Journal of Hypertension·Holly N ThomasUNKNOWN SPRINT Study Group
Feb 2, 2019·Archives of Gynecology and Obstetrics·Barbara SutterPetra Stute
Feb 22, 2003·CNS Spectrums·Robert Taylor Segraves
Nov 1, 2002·Current Opinion in Urology·Aristotelis G AnastasiadisRidwan Shabsigh
Jun 28, 2005·The Journal of Steroid Biochemistry and Molecular Biology·L BergerF Labrie

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