Decreased glial cell line-derived neurotrophic factor levels in patients with depression: a meta-analytic study

Journal of Psychiatric Research
Pao-Yen Lin, Ping-Tao Tseng

Abstract

Glial cell-line derived neurotrophic factor (GDNF) has been shown to promote development, differentiation, and protection of CNS neurons and was thought to play an important role in various neuropsychiatric disorders. Several studies have examined the GDNF levels in patients with depression but shown inconsistent results. In this study, we compared blood GDNF levels between depressive patients and control subjects through meta-analytic method. The effect sizes (ESs) from all eligible studies were synthesized by using a random effect model. In this meta-analysis, we included 526 patients and 502 control subjects from 12 original articles. Compared to control subjects, blood GDNF levels are significantly decreased in patients with depression (ES = -0.62, p = 0.0011). However, significant heterogeneity was found among included studies. Through subgroup analysis, we found that GDNF was still decreased in studies with major depressive disorder (ES = -0.73, p = 0.0001); in studies with non-old-age depression (ES = -1.25, p = 0.0001), but not with old-age depression; and in studies using serum samples (ES = -0.86, p < 0.0001), but not in studies using plasma sample. Meta-regression did not show moderating effects of mean age of subjec...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Aug 14, 1998·The Journal of Comparative Neurology·J P GoldenE M Johnson
May 4, 2002·Nature Reviews. Neuroscience·Matti S Airaksinen, Mart Saarma
Apr 4, 2003·Neuroscience Letters·Abba J KastinWeihong Pan
Sep 30, 2005·The International Journal of Neuropsychopharmacology·Minoru TakebayashiShigeto Yamawaki
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xiaobin ZhangWeiwei Sha
Mar 4, 2008·Journal of Psychiatric Research·Koji OtsukiYoshifumi Watanabe
Jun 10, 2008·Nature Neuroscience·Alberto PascualJosé López-Barneo
Sep 2, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Tanja M MichelEdna Grünblatt
Mar 26, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Luisella Bocchio-ChiavettoMassimo Gennarelli
Mar 31, 2010·Journal of Affective Disorders·Xiaobin ZhangYumei Zhang
Apr 29, 2011·Journal of Affective Disorders·Xiaoquan WangZhijun Zhang
Aug 9, 2011·Neuroscience Letters·Izabela Guimarães BarbosaAntônio Lúcio Teixeira
Oct 4, 2011·Journal of Psychiatric Research·Breno S DinizOrestes V Forlenza
Apr 13, 2012·Psychiatry Research·Leonardo F FontenelleAntonio Lucio Teixeira
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ronald S Duman, Nanxin Li
Aug 1, 2012·Journal of Molecular Neuroscience : MN·Anatoly UzdenskyAndrej Lobanov
Oct 2, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ping-Tao TsengPao-Yen Lin
Nov 6, 2012·Human Psychopharmacology·Janusz K RybakowskiAlicja Bartkowska-Sniatkowska
Dec 12, 2012·Neuropsychobiology·Monika Dmitrzak-WeglarzJoanna Hauser
May 8, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Hua SunWei He
Jun 19, 2013·Journal of Affective Disorders·Pooja PallaviAsok K Mukhopadhyay
Jul 23, 2013·Journal of Affective Disorders·Michele FornaroMatteo Martino
Jan 18, 2014·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Xiaobin ZhangYumei Zhang
Feb 11, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C SieversH J Grabe
Feb 22, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Stefan BittnerSven G Meuth
Jun 6, 2014·Neurochemical Research·Taiane de Azevedo CardosoJean Pierre Oses
Jun 12, 2014·Journal of Neuroscience Research·Juliann D Jaumotte, Michael J Zigmond

❮ Previous
Next ❯

Citations

Feb 2, 2016·Neurobiology of Disease·Carlos F Ibáñez, Jaan-Olle Andressoo
Feb 2, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xiao-Feng ZhangYi-Hua Xu
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Anand GururajanJohn F Cryan
Mar 10, 2016·Journal of Affective Disorders·Ajaykumar N SharmaJoao Quevedo
Jul 27, 2015·Psychoneuroendocrinology·André F CarvalhoMichael Berk
Jul 1, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ping-Tao TsengPao-Yen Lin
Sep 8, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Chiara FabbriAlessandro Serretti
Mar 23, 2017·Biochemistry. Biokhimii︠a︡·N K PopovaV S Naumenko
Aug 9, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Amit Singh, Sujita Kumar Kar
Feb 7, 2020·International Journal of Psychiatry in Clinical Practice·Ayhan BilgiçÖmer Faruk Akça
Jan 19, 2017·Reviews in the Neurosciences·Anton S TsybkoNina K Popova
May 19, 2017·Clinical Science·Aline Silva MirandaAna Cristina Simões E Silva
May 20, 2020·Translational Psychiatry·André F CarvalhoNathan Herrmann
Sep 8, 2017·Frontiers in Molecular Neuroscience·Daniel CortésIván Velasco
Aug 23, 2020·Brain Sciences·Matteo VismaraBernardo Dell'Osso
Jun 7, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yanxiaoxiao YangYonggui Yuan
Jul 28, 2019·Journal of Neural Transmission·Nicola LopizzoAnnamaria Cattaneo
Feb 8, 2019·Frontiers in Psychiatry·Zan WangFang Deng
May 5, 2018·Addiction Biology·Segev BarakDorit Ron
Jun 13, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·André R BrunoniIsabela Martins Benseñor
Apr 4, 2021·Journal of Personalized Medicine·Katarzyna Bliźniewska-KowalskaMonika Talarowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.