Decreased Glycemic Difference Between Diabetes and Nondiabetes in the Elderly Leads to the Reduced Diagnostic Accuracy of Hemoglobin A1c for Diabetes Screening in an Aged Chinese Population

Diabetes Technology & Therapeutics
Xiantong ZouLinong Ji

Abstract

This study investigated the impact of age on the accuracy of glycated hemoglobin (HbA1c) for diabetes screening and explored the possible cause(s). Data from 3,050 Chinese participants 25-75 years of age without known diabetes in a population-based cross-sectional survey were analyzed. Diabetes was diagnosed by the oral glucose tolerance test (OGTT). The performance of HbA1c for detecting OGTT-defined diabetes in tertile groups (divided by age) was evaluated by the area under the curve (AUC) of the receiver operating characteristic curve (ROC). The effect of age on the difference in glucose levels between participants with and without diabetes and the impact of this difference on the performance of HbA1c were evaluated. In young (25-41 years old), middle-aged (41-53 years old), and old (55-72 years old) participants, the ROC AUC (95% confidence interval) of HbA1c for detecting OGTT-defined diabetes was 0.958 (0.915, 1.000), 0.891 (0.852, 0.930), and 0.861 (0.821, 0.901), respectively (P = 0.005). The difference of fasting plasma glucose between participants with diabetes and those without diabetes decreased with increasing age: 3.01 (2.80, 3.22) mmol/L, 2.90 (2.71, 3.09) mmol/L, and 2.33 (2.16, 2.50) mmol/L in the three consecu...Continue Reading

References

Jan 1, 1986·Annals of Internal Medicine·R H Fletcher
Jul 9, 1994·BMJ : British Medical Journal·D G Altman, J M Bland
Oct 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·S Tsukui, I Kobayashi
Oct 27, 2001·Diabetes Care·E EschwègeUNKNOWN Paris Prospective Study
Mar 21, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·C M BennettS C Dharmage
May 31, 2007·Diabetes Care·William H HermanUNKNOWN Diabetes Prevention Program Research Group
Jun 10, 2008·Diabetes Care·David M NathanUNKNOWN A1c-Derived Average Glucose Study Group
Oct 20, 2009·Diabetes Care·Caroline K KramerElizabeth Barrett-Connor
Dec 17, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·X H ZhouQ Qiao
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenPaul Z Zimmet
Jan 24, 2012·Investigative Ophthalmology & Visual Science·Harsha L RaoChandra S Garudadri

❮ Previous
Next ❯

Software Mentioned

Stata
SPSS

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.