Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement

Scientific Reports
Ting YuYun Long Tan

Abstract

Tardive dyskinesia (TD) is a devastating motor disorder associated with the etiological process of schizophrenia or antipsychotic medication treatments. To examine whether cerebral morphological changes may manifest in TD, we used voxel-based morphometry to analyze high-resolution T1-weighted brain structural magnetic resonance images from 32 schizophrenics with TD (TD group), 31 schizophrenics without TD (non-TD group), and 32 healthy controls (HC group). We also assessed psychopathological symptoms with the Positive and Negative Syndrome Scale (PANSS), and TD severity with the Abnormal Involuntary Movement Scale (AIMS). We compared gray matter volumes (GMVs) among groups, and tested for correlations between GMV changes and psychopathological symptoms or TD severity. The results showed significant differences in GMV in the frontal and temporal cortices, insula and cerebellum among the three groups. Brainstem and inferior frontal and precentral gyri GMVs were significantly larger, whereas cuneus and lingual gyrus GMVs were significantly smaller in the TD group as compared to non-TD group. Further, the cuneus and lingual gyrus GMVs were positively correlated with AIMS scores in the TD group. The current results suggest that TD m...Continue Reading

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Citations

Feb 5, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Lauren E SalminenPaul M Thompson
May 4, 2021·The Australian and New Zealand Journal of Psychiatry·Zuxing WangXingguang Luo
Jun 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dusan HirjakRobert C Wolf
Oct 15, 2021·Brain Imaging and Behavior·Yuxiang GuoMiaomiao Liu

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