DOI: 10.1101/487538Dec 4, 2018Paper

Decreased grey matter volume in mTBI patients with post-traumatic headache compared to headache-free mTBI patients and healthy controls: a longitudinal MRI study

BioRxiv : the Preprint Server for Biology
Shana A.B. BurrowesDavid A. Seminowicz


Background: Traumatic brain injury (TBI) occurs in 1.7 million people annually and many patients go on to develop persistent disorders including post-traumatic headache (PTH). PTH is considered chronic if it continues past 3 months. In this study we aimed to identify changes in cerebral grey matter volume (GMV) associated with PTH in mild TBI patients. Methods: 50 mTBI patients (31 Non-PTH; 19 PTH) underwent MRI scans: within 10 days post-injury, 1 month, 6 months and 18 months. PTH was assessed at visit 4 by a post-TBI headache questionnaire. Healthy controls (n=21) were scanned twice 6 months apart. Results: Compared to non-PTH, PTH patients had decreased GMV across two large clusters described as the right anterior-parietal (p=0.012) and left temporal-opercular (p=0.027). Compared to healthy controls non-PTH patients had decreased GMV in the left thalamus (p=0.047); PTH patients had decreased GMV in several extensive clusters: left temporal-opercular (p=0.003), temporal-parietal (p=0.041), superior frontal gyrus (p=0.008) and right middle frontal/superior frontal gyrus (0.004) and anterior-parietal (p=0.003). Conclusion: Differences between PTH and non-PTH patients were most striking at early time points. These early changes...Continue Reading

Related Concepts

Gene Clusters
Gray Matter
Longitudinal Studies
Magnetic Resonance Imaging
Post-Traumatic Headache
Structure of Superior Frontal Gyrus
Structure of Parietal Branch of Superficial Temporal Artery
Chronic Post-traumatic Headache

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.