DOI: 10.1101/487538Dec 4, 2018Paper

Decreased grey matter volume in mTBI patients with post-traumatic headache compared to headache-free mTBI patients and healthy controls: a longitudinal MRI study

BioRxiv : the Preprint Server for Biology
Shana A.B. BurrowesDavid A. Seminowicz

Abstract

Background: Traumatic brain injury (TBI) occurs in 1.7 million people annually and many patients go on to develop persistent disorders including post-traumatic headache (PTH). PTH is considered chronic if it continues past 3 months. In this study we aimed to identify changes in cerebral grey matter volume (GMV) associated with PTH in mild TBI patients. Methods: 50 mTBI patients (31 Non-PTH; 19 PTH) underwent MRI scans: within 10 days post-injury, 1 month, 6 months and 18 months. PTH was assessed at visit 4 by a post-TBI headache questionnaire. Healthy controls (n=21) were scanned twice 6 months apart. Results: Compared to non-PTH, PTH patients had decreased GMV across two large clusters described as the right anterior-parietal (p=0.012) and left temporal-opercular (p=0.027). Compared to healthy controls non-PTH patients had decreased GMV in the left thalamus (p=0.047); PTH patients had decreased GMV in several extensive clusters: left temporal-opercular (p=0.003), temporal-parietal (p=0.041), superior frontal gyrus (p=0.008) and right middle frontal/superior frontal gyrus (0.004) and anterior-parietal (p=0.003). Conclusion: Differences between PTH and non-PTH patients were most striking at early time points. These early changes...Continue Reading

Related Concepts

Gene Clusters
Gray Matter
Longitudinal Studies
Magnetic Resonance Imaging
Persons
Post-Traumatic Headache
Structure of Superior Frontal Gyrus
Structure of Parietal Branch of Superficial Temporal Artery
Operculum
Chronic Post-traumatic Headache

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