PMID: 8962714Jan 1, 1996Paper

Decreased growth hormone receptor expression in long bones from toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1

Growth Factors
A L SymonsS C Marks

Abstract

Growth hormone (GH) is known to regulate growth and development of skeletal tissues. This study examined the distribution of growth hormone receptor (GHR) expression in tibias from normal and osteopetrotic tl/tl rats. For normal 2 week-old rats, GHR expression was detected immunocytochemically in cells of the articular and epiphyseal cartilage, primary and secondary ossification centres, zone of resting cartilage and bone marrow. Within the marrow, GHR immunopositive cells were concentrated in the central cone and largely excluded from the zone of immature progenitors at the periphery. For the marrow haemopoietic compartment, GHR expression was almost restricted to the nucleus in large mononuclear cells, adipocytes and megakaryocytes. A population of small lymphocytelike cells in the marrow periphery expressed GHR on the plasma membrane. GHR was not detected in mature erythroid cells, macrophages, granulocytes, or osteoclasts. The expression of GHR was significantly reduced in bone marrow cells of the tl/tl rat (p < 0.001) compared with normal animals. Injection of recombinant CSF-1 into tl/tl rats every 48 hours for 2 weeks from birth restored GHR-positive cells to the central core of the marrow space. The most striking change...Continue Reading

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Citations

May 13, 1999·Brain Research. Molecular Brain Research·A ScheepensC E Williams
Oct 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Liesbeth Van WesenbeeckSandy C Marks
Oct 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A C WardJ A Hamilton
Feb 3, 1999·Annals of the New York Academy of Sciences·M D Grounds
Feb 14, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·D A SomersetM D Kilby
Jan 1, 1997·Growth Factors·L AustinC M Muldoon
Jan 3, 2001·Developmental Biology·F LupuA Efstratiadis
Jan 1, 1997·The Australian and New Zealand Journal of Surgery·M J Lawson-Smith, J K McGeachie
Sep 27, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clare PridansDavid A Hume
Jun 4, 2010·Journal of Leukocyte Biology·Deborah J GowDavid A Hume
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·U Ripamonti, A H Reddi

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