Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis

European Journal of Clinical Investigation
M BertolottiN Carulli

Abstract

Cholesterol cholelithiasis (gallstone disease) is a common disease in the Western world. The aim of the present study was to analyze the hepatic expression of a number of nuclear receptors involved in bile acid metabolism in human cholesterol gallstone disease. Surgical liver biopsies were obtained from 11 patients with untreated cholesterol cholelithiasis and nine gallstone-free subjects; mRNA levels of cholesterol 7alpha-hydroxylase (CYP7A1) and related nuclear receptors and coactivators were assayed by quantitative real-time RT-PCR. No differences between the two groups were detected in mRNA levels of CYP7A1 and related nuclear receptors, with the exception of peroxysome proliferator-activated receptor-gamma coactivator 1 (PGC-1), which was significantly (P < 0.01) less expressed in gallstone subjects. Expression of PGC-1 was linearly correlated with farnesoid X receptor (FXR) in gallstone patients (r = 0.87 on a log scale, P < 0.01), but not in control subjects; in gallstone patients PGC-1 expression was also correlated with hepatocyte nuclear factor 4 (HNF-4) (r = 0.78, P < 0.01). These findings suggest that PGC-1 can play a role in the prevention of cholesterol gallstone disease in humans; this might take place via intera...Continue Reading

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Citations

Jan 28, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Hyun Woo ByunJin Lee
Jan 8, 2016·Annual Review of Pharmacology and Toxicology·Swetha RudraiahLi Wang
Jun 1, 2007·European Journal of Clinical Investigation·M BertolottiN Carulli
Apr 2, 2013·Clinics in Liver Disease·Emina HalilbasicMichael Trauner
Sep 7, 2007·Molecular Cell·David M Lonard, Bert W O'malley
Dec 18, 2013·Molecular Aspects of Medicine·Anna BaghdasaryanMichael Trauner
Feb 22, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco BertolottiMarina Del Puppo
Oct 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marco BertolottiNicola Carulli
Apr 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mats Rudling
Jul 5, 2007·Endocrine Reviews·David M LonardBert W O'Malley
Oct 18, 2008·Physiology·Jyrki J Eloranta, Gerd A Kullak-Ublick
Jul 26, 2021·European Journal of Pharmacology·Swarne EK L Krishna

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