PMID: 3745878Jan 1, 1986Paper

Decreased hepatic glutathione in chronic alcoholic patients

Journal of Hepatology
S A JewellO Albano

Abstract

The metabolism of ethanol can result in depletion of reduced glutathione (GSH) via adduct formation and oxidation to GSSG. In this study, the glutathione concentration in liver tissue of chronic alcoholic patients (n = 20) was measured using a specific chromatographic method. The results are compared to values obtained from a group of selected controls (n = 10), and correlated to liver histology and blood biochemistry. All of the alcoholics had markedly lower hepatic GSH concentrations than the control group (medians = 2.17 vs 3.88 mumol/g liver, respectively). No significant differences in liver GSH were found among alcoholic subgroups who had slightly altered or normal histology and/or blood tests vs those with advanced pathology. A decrease in hepatic GSH concentration seems to be a consistent characteristic of chronic alcohol abuse which occurs even in the absence of evident liver damage.

References

Oct 1, 1974·Clinical Pharmacology and Therapeutics·J R MitchellH Keiser
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·C Guerri, S Grisolía
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Jan 1, 1984·The Medical Clinics of North America·C S Lieber
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Schenker
Jan 1, 1982·Pharmacological Research Communications·C P SiegersD Oltmanns
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·H E PoulsenP B Andreasen
Apr 1, 1980·Annals of Internal Medicine·H LichtH J Zimmerman
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN

❮ Previous
Next ❯

Citations

Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E PuruckerG Krandik
Jul 1, 1990·Toxicology·B GeorisR Lauwerys
May 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L BattistonG Pozzato
Apr 4, 2013·Journal of Ethnopharmacology·Min-Kyung ChoiChang-Gue Son
Aug 23, 2001·Pharmacology & Therapeutics·A Bomzon, P Ljubuncic
Jul 1, 1996·Journal of Hepatology·I GrattaglianoE Altomare
Jan 1, 1992·Journal of Gastroenterology and Hepatology·T ShigesawaF Marumo
Jun 1, 1993·Alcoholism, Clinical and Experimental Research·B HultbergA Frank
May 24, 2001·Alcoholism, Clinical and Experimental Research·M E GötzJ Böning
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·M MossL A Brown
Aug 13, 2002·American Journal of Veterinary Research·Sharon A CenterHollis N Erb
Jan 8, 1999·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E PuruckerS Matern
Jul 7, 2009·The Medical Clinics of North America·Gaurav Mehta, Kenneth D Rothstein
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Zhenyuan SongCraig McClain
May 4, 2013·Alimentary Pharmacology & Therapeutics·J H Lewis, J G Stine
Jun 11, 2011·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Jean-Sebastien Rachoin, Elizabeth A Cerceo
Aug 1, 1988·European Journal of Clinical Investigation·J M BurgunderB H Lauterburg
Mar 10, 2001·Clinics in Liver Disease·W C Maddrey
Apr 1, 1987·Journal of Hepatology·B H Lauterburg, J R Mitchell
Sep 26, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Poonam LodhiMonu Kumar
Jul 5, 2001·Toxicology and Applied Pharmacology·T R Fennell, C D Brown
Oct 1, 2007·Expert Review of Respiratory Medicine·Matthew ProutDavid M Guidot
Jun 26, 2017·Journal of Ethnopharmacology·Yuanheng GuoBing Zhao
Apr 10, 2002·American Journal of Therapeutics·Bernhard H Lauterburg
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan B MiñanaJuan Sastre
Aug 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F LunelP Opolon
Mar 16, 2005·American Journal of Therapeutics·Gordon D BensonKeith G Tolman
Jan 30, 2004·European Journal of Clinical Nutrition·F ZengerB H Lauterburg
Jan 16, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pratibha C Joshi, David M Guidot
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·W C Maddrey
May 1, 1989·Scandinavian Journal of Gastroenterology·G VendemialeO Albano
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Y HanH Ishii

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.