Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Yvette I ShelineStephen M Moerlein

Abstract

Serotonin receptor changes have been associated with the pathophysiology and treatment of major depression. Only one other study has investigated serotonin receptor changes in older depressed patients. We used positron emission tomography (PET) and [18F]altanserin, a ligand with high affinity for the 5-HT(2A) receptor, to examine the relationship between 5-HT(2A) receptor density and depression. Depressed subjects (n = 16), age > 50 years, were recruited as part of a larger study. Older depressed subjects consisted of early-onset recurrent depression (EORD, n = 11) and late-onset depression (LOD, n = 5). An age-matched control group (n = 9) was also recruited. All subjects were right-handed, nonsmokers and antidepressant-free. Regions of interest were determined on a summed MPRAGE scan transformed into Talairach space and coregistered with the PET images. Depressed subjects had less hippocampal 5-HT(2A) receptor binding than controls (p = 0.05). No significant differences in receptor binding were found between EORD and LOD subjects. Depressed subjects not previously treated for depression (n = 6) had less hippocampal 5-HT(2A) receptor binding (p = 0.04) than previously treated subjects (n = 10). It may be that prior medication ...Continue Reading

References

Mar 8, 1988·Brain Research·S C CheethamR W Horton
Oct 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·R J JacobyJ M Bird
Nov 1, 1981·Acta Psychiatrica Scandinavica·M BaronJ Klotz
Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
Apr 1, 1997·The American Journal of Psychiatry·K R KrishnanD G Blazer
Jul 1, 1997·Archives of General Psychiatry·R S DumanE J Nestler
Feb 17, 1998·The British Journal of Psychiatry : the Journal of Mental Science·F BiverJ Mendlewicz
Jan 5, 2000·The American Journal of Psychiatry·J D BremnerD S Charney
Sep 15, 2000·Archives of General Psychiatry·L N YathamT J Ruth
Jan 4, 2001·The American Journal of Psychiatry·J H MeyerS H Kennedy
May 2, 2001·The British Journal of Psychiatry : the Journal of Mental Science·L N YathamT J Ruth
Mar 1, 2002·The American Journal of Psychiatry·Yvette I ShelineAbraham Z Snyder
Aug 3, 2002·The American Journal of Psychiatry·Sandra Bell-McGintyJames T Becker
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Glenda M MacQueenL Trevor Young
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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Citations

Apr 13, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Qiaozhen ChenMei Tian
May 19, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhu LiHerbert Y Meltzer
Aug 25, 2010·Journal of Psychiatry & Neuroscience : JPN·Nikolai V MalykhinNicholas J Coupland
Dec 3, 2014·Archives of Psychiatric Nursing·Ezra C Holston
Feb 16, 2013·Expert Opinion on Investigational Drugs·Tiago A MestreSusan H Fox
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Apr 10, 2012·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Jul 1, 2009·Neurochemistry International·V TrajkovskaS Aznar
Apr 22, 2009·Experimental Neurology·Viktorija TrajkovskaSusana Aznar
May 29, 2009·The European Journal of Neuroscience·H-P Landolt, R Wehrle
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Luc Zimmer, Didier Le Bars
Jun 16, 2011·Medicinal Research Reviews·Louise M PatersonGitte M Knudsen
Mar 31, 2009·Brain Research·Robert J UrsanoDavid M Benedek
Aug 5, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Yosuke YamawakiShigeto Yamawaki
Oct 4, 2011·Journal of Psychiatric Research·Breno S DinizOrestes V Forlenza
Jan 26, 2007·The International Journal of Neuropsychopharmacology·Bella SmolinDorit Ben-Shachar
Jul 23, 2016·Journal of Alzheimer's Disease : JAD·Janina Krell-RoeschYonas E Geda
Jan 8, 2014·Journal of Geriatric Psychiatry and Neurology·Kentaro Hirao, Gwenn S Smith
Aug 29, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Abraham MartínJordi Llop
Dec 28, 2017·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·J John MannDavid A Brent

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