Decreased IFN- gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients

Tuberculosis
S M SmithH M Dockrell

Abstract

To investigate the role of MHC class I restricted CD8(+) T cells in host defense to M. tuberculosis, peripheral blood mononuclear cells (PBMC) from healthy BCG-vaccinated donors and untreated pulmonary tuberculosis (TB) patients in The Gambia were stimulated for 6 days with M. bovis BCG or M. tuberculosis and the CD8(+) T cell response analyzed. Intracellular FACS analysis of cytokine production by CD8(+) T cells showed that IFN- gamma and TNF- alpha production were greatly reduced in TB patients compared to healthy controls. IL-4-producing CD8(+) T cells were detected in TB patients, a phenotype absent in controls. Collectively, these data suggest that an alteration in the type 1/type 2 cytokine balance occurs in CD8(+) T cells during clinical tuberculosis, and that this may provide a surrogate marker for disease.

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Citations

Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristina EdfeldtRobert L Modlin
Nov 1, 2006·Critical Reviews in Immunology·Joshua S M Woodworth, Samuel M Behar
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Nov 28, 2009·Vaccine·Maeve K LalorHazel M Dockrell
Oct 27, 2017·Annals of Laboratory Medicine·Zhong Bo ShangLi Hua Huang
Jul 1, 2014·The Journal of Pathology·Lisa HeitmannChristoph Hölscher
May 11, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wei LuoLi Ma
Dec 21, 2011·Ethnicity & Health·Sylvia Reitmanova, Diana L Gustafson
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacqueline M CliffHazel M Dockrell
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadia CaccamoAlfredo Salerno
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Jun 25, 2003·Current Opinion in Infectious Diseases·Eun-Kyeong JoHazel M Dockrell

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