Decreased incidence of spontaneous mammary gland neoplasms in female F344 rats treated with amphetamine, methylphenidate, or codeine

Cancer Letters
J K DunnickJ K Haseman

Abstract

Three drugs that affect the neuroendocrine system (amphetamine, methylphenidate, and codeine) caused decreases in body weights and in the incidence of spontaneously occurring mammary gland neoplasms in the female F344/N rat in 2-year carcinogenicity studies. Using a mathematical model that relates body weight changes to the incidence of mammary gland neoplasms, we find that the decrease in mammary gland tumours seen in female rats cannot be fully explained by body weight decreases relative to control animals. Further, the observed decreases in body weight in treated female rats were not a function of differences in feed consumption between treated and control groups. These pharmaceuticals are thought to affect the biologic system through interaction with membrane receptors. This interaction and/or subsequent cell signaling events may play a role in the observed decrease in spontaneously occurring mammary gland neoplasms in the female rat treated with amphetamine, methylphenidate, or codeine.

References

Dec 28, 1992·Science·C J EvansR H Edwards
Jun 1, 1991·Current Opinion in Neurobiology·J Bockaert
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R Maneckjee, J D Minna
May 1, 1990·Endocrine Reviews·M A Carson-JuricaB W O'Malley
Feb 10, 1989·Cell·M Beato
Dec 3, 1987·The New England Journal of Medicine·D G BostwickK G Bensch
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·S NandiJ Yang
Feb 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S K Seilkop
May 3, 1995·Journal of the National Cancer Institute·V C Jordan
Mar 15, 1995·Journal of the National Cancer Institute·N RoodiF F Parl
Dec 1, 1995·Toxicology Letters·G A BoormanR A Herbert

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Citations

Nov 22, 2005·Cancer Letters·Randa A El-ZeinMarvin S Legator
Jul 31, 2003·Medical Hypotheses·E Lundsgaard
Jun 15, 2006·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Martin HoltmannFritz Poustka
Nov 18, 2004·Regulatory Toxicology and Pharmacology : RTP·Henk TennekesBennard van Ravenzwaay
May 1, 1997·Toxicologic Pathology·J K HasemanJ R Hailey

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