PMID: 8941511Nov 1, 1996Paper

Decreased insulin action on muscle glucose transport after eccentric contractions in rats

Journal of Applied Physiology
S Asp, E A Richter

Abstract

We have recently shown that eccentric contractions (Ecc) of rat calf muscles cause muscle damage and decreased glycogen and glucose transporter GLUT-4 protein content in the white (WG) and red gastrocnemius (RG) but not in the soleus (S) (S. Asp, S. Kristiansen, and E. A. Richter. J. Appl. Physiol. 79: 1338-1345, 1995). To study whether these changes affect insulin action, hindlimbs were perfused at three different insulin concentrations (0, 200, and 20,000 microU/ml) 2 days after one-legged eccentric contractions of the calf muscles. Compared with control, basal glucose transport was slightly higher (P < 0.05) in Ecc-WG and -RG, whereas it was lower (P < 0.05) at both submaximal and maximal insulin concentrations in the Ecc-WG and at maximal concentrations in the Ecc-RG. In the Ecc-S, the glucose transport was unchanged in hindquarters perfused in the absence or presence of a submaximal stimulating concentration of insulin, whereas it was slightly (P < 0.05) higher during maximal insulin stimulation compared with control S. At the end of perfusion the glycogen concentrations were lower in both Ecc-gastrocnemius muscles compared with control muscles at all insulin concentrations. Fractional velocity of glycogen synthase increas...Continue Reading

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Citations

Mar 29, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Katie May SlatteryAaron James Coutts
Aug 1, 2013·Physiological Reviews·Erik A Richter, Mark Hargreaves
Jan 11, 2005·Journal of the American College of Nutrition·William J Evans
Dec 14, 2018·Journal of Applied Physiology·Ole Emil AndersenKristian Overgaard
May 18, 1999·The American Journal of Physiology·L F del AguilaJ P Kirwan
Mar 19, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·W J Evans
Apr 27, 2004·Sports Medicine·Charles P LambertWilliam J Evans
Mar 10, 2000·Journal of Applied Physiology·J M HernandezP A Farrell
Oct 24, 2002·Clinical Orthopaedics and Related Research·William J Evans

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