Decreased interstitial FOXP3(+) lymphocytes in usual interstitial pneumonia with discrepancy of CXCL12/CXCR4 axis.

International Journal of Immunopathology and Pharmacology
Y ShimizuM Mori

Abstract

Regulatory T cells (Treg) play a critical role in immune homeostasis and expansion of Treg is controlled by chemokine receptors. The chemokine CXCL12 and its G-protein-coupled receptor (CXCR4) are involved in the development of idiopathic pulmonary fibrosis (IPF), but the association of Treg with the CXCL12/CXCR4 axis has not been documented. The aim of this study is to determine the distribution and extent of CXCL12/CXCR4 expression in idiopathic type of pulmonary fibrosis, and the relation of Treg expansion in the interstitium of pulmonary fibrosis patients to CXCL12/CXCR4 expression. CXCL12 expression was examined by immunostaining and ELISA in tissue specimens from patients with usual interstitial pneumonia (UIP, n=15), patients with fibrotic non-specific interstitial pneumonia (f-NSIP, n=4), and controls (n=6). CXCR4 expression was examined by in situ hybridization and immunoblotting. Expression of CD45, CD3, CD20, transcription factor forkhead box P3 (FOXP3), and CD25 was assessed by immunostaining. Fibrosis was evaluated by determining the established fibrosis (EF) score. The CXCL12/CXCR4 axis was upregulated in UIP and f-NSIP, and CXCL12 derived from lung tissue attracted CXCR4(+) cells. CXCR4(+) cells showed a CD3(+) c...Continue Reading

References

Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·Y ShimizuM Mori
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Andrew G NicholsonAthol U Wells
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May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Mar 25, 2009·International Journal of Immunopathology and Pharmacology·Y ShimizuM Mori
Apr 4, 2009·American Journal of Respiratory and Critical Care Medicine·Ioannis KotsianidisDemosthenes Bouros
Apr 10, 2010·International Journal of Immunopathology and Pharmacology·H ImaiM Mori

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Citations

Jan 13, 2015·Frontiers of Medicine·Bethany B MooreUNKNOWN The COMET Investigators
Mar 29, 2014·International Journal of Immunopathology and Pharmacology·Y ShimizuM Yamada
Jan 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shannon H LacyPatricia J Sime
Dec 23, 2011·Clinical & Developmental Immunology·F PandolfiC Barone
Apr 26, 2020·International Immunopharmacology·Fuquan WangShanglong Yao
Jun 19, 2016·The American Journal of Pathology·Shirin Z BirjandiJohn A Belperio
May 18, 2021·Frontiers in Immunology·Chiel van GeffenSaeed Kolahian

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