Decreased level of osteopontin in children with allergic rhinitis during sublingual immunotherapy

International Journal of Pediatric Otorhinolaryngology
Chunrui WangTianhong Zhang

Abstract

Sublingual immunotherapy (SLIT) is proven to be very effective in the treatment of allergic rhinitis (AR), but its regulatory mechanism and biomarkers for predicting efficacy are still unknown. Osteopontin (OPN), as a recently described Th2 inflammation related protein, plays key role in the pathogenesis of AR. The aim of this study was to identify the expression and role of OPN during SLIT in children. Fifty house dust mite (HDM)-sensitized children with AR were enrolled in this study. AR children received HDM allergen extract or placebo for SLIT. Serum of different time points during treatment was collected and used for enzyme-linked immuno sorbent assay (ELISA) of OPN and related cytokines, respectively. Peripheral blood mononuclear cells from children after SLIT or placebo treatment were collected and stimulated with HDM with or without OPN/anti-OPN after one year's treatment. Our results showed that expression of OPN protein was decreased after one year's therapy. The decreased OPN expression was positively related to decreased Th2 cytokines and negatively related to enhanced IL-10 and TGF-β expression. In vitro experiments confirmed that children received SLIT treatment showed decreased production of Th2 cytokines by PBMC...Continue Reading

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Citations

Oct 6, 2018·Allergy·Ibon Eguiluz-GraciaMaria J Torres
Apr 1, 2020·Pediatric Blood & Cancer·Nasenien Nourkami-TutdibiErol Tutdibi
Apr 25, 2020·International Forum of Allergy & Rhinology·Liang ChenTianlin Li
May 24, 2018·Indian Journal of Pediatrics·Yuanming WangXianglin Luo
Jun 21, 2018·Allergologia et immunopathologia·L Cheng, W-C Zhou
Sep 1, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Jin Youp KimDoo Hee Han

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