Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium

Molecular Human Reproduction
Shirly Lahav-BaratzMartha Dirnfeld

Abstract

p27 is a cyclin-dependent kinase (CDK) inhibitor whose specific late G(1) destruction allows progression of the cell across the G(1)/S boundary. The protein is ubiquitinated by S-phase kinase-interacting protein-2 (Skp2) following its specific phosphorylation, and is subsequently degraded by the 26s proteasome. There is a direct relationship between low level of p27 and rapid proliferation occurring in several benign states and in many malignancies. In the glandular cells of the normal endometrium, the level of p27 is exceedingly low during the proliferative phase, whereas it is markedly increased during the secretory phase. The expression of p27 in endometrial carcinoma is very low but has been found to increase following treatment with progesterone. However, estrogen exposure is considered as a major risk factor in developing endometrial cancer. The implications of the high dose of estrogen and progesterone induced during IVF treatment are still unknown. We have examined the expression of p27 and Skp2 as well as of Ki67 proliferation marker by using endometrial extracts and cells from normal endometrium, from ovarian hyperstimulated patients, and from endometrial carcinoma patients. The expression of p27, Skp2 and Ki67 was fo...Continue Reading

Citations

Aug 5, 2005·Journal of Cancer Research and Clinical Oncology·Yuko KamataHiroyuki Kuramoto
May 27, 2008·Nature Reviews. Cancer·David Frescas, Michele Pagano
Aug 2, 2012·American Journal of Physiology. Endocrinology and Metabolism·Xiaohua GaoDarlene Dixon
Jun 13, 2009·World Journal of Gastroenterology : WJG·Jun ChenChang-Sheng Deng
Dec 3, 2015·Expert Opinion on Pharmacotherapy·Christopher de HayduAlessandro D Santin
Jan 23, 2016·Reproductive Biomedicine Online·Shirly Lahav-BaratzMartha Dirnfeld
Mar 7, 2008·Fertility and Sterility·Eduardo SchorVilmon de Freitas
Aug 13, 2009·International Journal of Cancer. Journal International Du Cancer·James M HaughianAndrew P Bradford
Aug 30, 2008·Journal of Korean Medical Science·Sabarish RamachandranChi-Heum Cho
Mar 10, 2010·Biochemistry. Biokhimii︠a︡·A V SorokinL P Ovchinnikov
Apr 25, 2006·Nature Reviews. Cancer·Keiichi I Nakayama, Keiko Nakayama
Jan 13, 2012·The Journal of Clinical Endocrinology and Metabolism·D GonzalezR S Conlan
Aug 20, 2009·Cancer Research·Sharanjot SainiRajvir Dahiya

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