Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome

Journal of Gastroenterology and Hepatology
Eisuke IwasakiToshifumi Hibi

Abstract

Body mass index (BMI) and obesity are reportedly associated with symptoms of gastroesophageal reflux disease (GERD). The present study was designed to investigate the effect of metabolic disorders including obesity on the levels of functional gastroesophageal reflux by videoesophagography. Twenty-one patients with GERD-associated symptoms were examined by videoesophagography. On their initial visit, all patients completed the Japanese version of the Carlsson-Dent self-administered questionnaire (QUEST). The findings of videoesophagography were evaluated by the X-ray severity scores for gastroesophageal reflux (XRSS), which were defined for the total diagnosis of functional gastroesophageal reflux. Correlation between XRSS scores and physical or metabolic markers was evaluated. The mean XRSS in the QUEST-positive group (4.7+/-0.6) was significantly higher than that in the QUEST-negative group (3.3+/-0.5, P<0.05). XRSS correlated positively with BMI (P<0.05) and waist circumference (P<0.05), but negatively with high-density lipoprotein-cholesterol (P<0.05), serum adiponectin (P<0.05) and active ghrelin (P<0.05). In the multivariate analysis, serum adiponectin level, BMI and triglyceride independently affected the XRSS. Videoesoph...Continue Reading

References

Jul 1, 1997·Diabetes Care·S M HaffnerM P Stern
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Oct 29, 2000·The American Journal of Gastroenterology·A Meining, M Classen
Apr 6, 2001·Diabetes·M TschöpM L Heiman
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N BarakM D Sitrin
Apr 23, 2003·FEBS Letters·Tatsuhiro MasaokaHiromasa Ishii
Aug 3, 2005·Annals of Internal Medicine·Howard HampelHashem B El-Serag
Oct 8, 2005·Scandinavian Journal of Gastroenterology·Ikuyo MishimaYoshikazu Kinoshita
Mar 15, 2006·Gastroenterology·John E PandolfinoPeter J Kahrilas
Jun 2, 2006·The New England Journal of Medicine·Brian C JacobsonCarlos A Camargo
Nov 28, 2006·Gut·Hashem B El-SeragJennifer R Kramer
Feb 28, 2007·Gastroenterology·Justin Che-Yuen WuJoseph Jao-Yiu Sung

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Citations

Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Ken KishidaIichiro Shimomura
Nov 13, 2009·Journal of Gastroenterology·Juntaro MatsuzakiToshifumi Hibi
May 3, 2011·Cytokine & Growth Factor Reviews·Elisavet K TiakaSpyros P Potamianos
May 21, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J MatsuzakiT Hibi
Apr 7, 2015·Journal of Neurogastroenterology and Motility·Su Youn NamJeong Seon Kim
Jun 12, 2014·United European Gastroenterology Journal·Hidekazu SuzukiToshifumi Hibi
Aug 23, 2020·Journal of Clinical Medicine·Toshihiro NishizawaHidekazu Suzuki
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Mohamed N RafatAhmed Abd El Aziz El Sayed Atiia
Oct 13, 2020·Journal of Clinical Biochemistry and Nutrition·Chung Hyun TaeSun Ha Jee
Jan 1, 2021·Journal of Neurogastroenterology and Motility·Ofer Z Fass, Hiroshi Mashimo

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