PMID: 7518657Aug 15, 1994Paper

Decreased levothyroxine requirement in women with hypothyroidism during androgen therapy for breast cancer

Annals of Internal Medicine
B M Arafah

Abstract

To determine the effects of androgen administration on measures of thyroid function and thyroid hormone replacement doses in women with breast cancer. Consecutive patients with metastatic, hormone-dependent breast cancer who were eligible for androgen treatment. Androgen therapy (fluoxymesterone, 10 mg orally twice daily) was continued for as long as it was effective in controlling tumor growth. 7 patients with no known thyroid disease and 4 others receiving long-term treatment for hypothyroidism. Serum levels of total and free thyroxine (T4), thyroid-stimulating hormone (TSH), and T4-binding globulin were determined before and every 4 weeks after androgen therapy was initiated. Within 4 weeks of androgen administration to the seven patients without thyroid disease, serum levels of total T4 and T4-binding globulin decreased (P < 0.001), whereas the calculated free thyroxine index and measured free hormone levels remained unchanged. Six to 12 weeks after androgen therapy was discontinued, all seven patients remained clinically euthyroid, and serum levels returned to baseline values. In contrast, clinical hyperthyroidism developed shortly after androgen was administered to four patients who received long-term thyroid hormone repl...Continue Reading

Citations

Apr 24, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Anna Maria AloisiMichelangelo Buonocore
Dec 21, 1995·The New England Journal of Medicine·M I Surks, R Sievert
Jun 9, 2001·The New England Journal of Medicine·B M Arafah
Jun 9, 2001·The New England Journal of Medicine·R D Utiger
Jan 31, 2004·Thyroid : Official Journal of the American Thyroid Association·Jeffrey M ZigmanJeffrey R Garber
May 15, 2004·Thyroid : Official Journal of the American Thyroid Association·Michael T McDermott
May 15, 2004·Thyroid : Official Journal of the American Thyroid Association·Norman A Mazer
Aug 14, 1999·Thyroid : Official Journal of the American Thyroid Association·G A Brent
Jul 2, 2003·Obstetrical & Gynecological Survey·Norman A Mazer, Jan L Shifren
Jan 25, 2005·Drugs & Aging·Peter LaurbergAllan Carlé
Oct 1, 2014·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasUNKNOWN American Thyroid Association Task Force on Thyroid Hormone Replacement
Nov 28, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Rundsarah Tahboub, Baha M Arafah
Mar 29, 2014·British Journal of Haematology·Payal P KhinchaSharon A Savage
Aug 1, 2015·Journal of the American Heart Association·Jaskanwal D SaraAmir Lerman
Jul 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·M M Kaplan
May 4, 2018·Frontiers in Endocrinology·Salvatore BenvengaAlessandro Antonelli
May 20, 2000·Annals of the New York Academy of Sciences·A G Doufas, G Mastorakos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.