PMID: 11336879May 5, 2001Paper

Decreased maternal serum leptin in pregnancies complicated by preeclampsia

Journal of the Society for Gynecologic Investigation
T LamlP Wagenbichler

Abstract

To determine whether circulating levels of leptin differed between women with preeclampsia and women who had an uncomplicated pregnancy. Maternal and umbilical venous plasma leptin concentrations obtained at delivery were compared in 36 pairs of women with either preeclampsia or normal pregnancy, matched 1:1 for prepregnancy body mass index and fetal gestational age at delivery. Prepregnancy body mass index was 21.1 +/- 2.1 kg/m2 in either study group (range 17.6-25.3 kg/m2 and 17.7-25.3 kg/m2 in the normal and preeclamptic group, respectively). Mean fetal gestational age at delivery was 40.1 +/- 1.3 weeks and 40.1 +/- 1.2 weeks in the normal and preeclamptic group, respectively. Median leptin concentrations were significantly lower (P <.0001) in women with preeclampsia (8.3 ng/mL, range 3.5-20.0 ng/mL) than in normal pregnant women (20.2 ng/mL, range 6.0-63.7 ng/mL). Median umbilical venous leptin was not significantly different between groups (preeclampsia 11.8 ng/mL, range 2.0-37.2 ng/mL; normal 7.6 ng/mL, range 1.6-24.3 ng/mL; P = .377). Umbilical venous leptin levels correlated positively with birth weight in both groups (preeclampsia rho = 0.501, P = .002; normal rho = 0.517, P = .001), whereas no correlations were found ...Continue Reading

References

Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Nov 1, 1996·Diabetes·J F CaroR V Considine
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W KiessW F Blum
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·N F ButteM A Nicolson
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·C SchubringW F Blum
Mar 10, 1998·Obstetrics and Gynecology·T TamuraS P Cliver
Apr 16, 1998·Acta Obstetricia Et Gynecologica Scandinavica·N SattarA M Wallace
Mar 17, 1999·American Journal of Obstetrics and Gynecology·J F McCarthyJ M Roberts
Feb 26, 2000·Metabolism: Clinical and Experimental·H LaivuoriO Ylikorkala

❮ Previous
Next ❯

Citations

Oct 16, 2007·Journal of Physiology and Biochemistry·U OzdemirT Erselcan
Jul 10, 2003·Clinics in Laboratory Medicine·Deirdre J LyellLinda C Giudice
Jun 3, 2011·Metabolism: Clinical and Experimental·Maria DalamagaChristos S Mantzoros
Feb 23, 2010·Medical Hypotheses·Andrea L Tranquilli, Beatrice Landi
Sep 29, 2011·Clinical Endocrinology·Konstanze MiehleMathias Fasshauer
Jun 21, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Margaret MellerMichelle A Williams
Feb 20, 2015·Archives of Gynecology and Obstetrics·Michail KalinderisBasil C Tarlatzis
May 8, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yingna SongJuntao Liu
May 29, 2009·Reproductive Sciences·Despina D Briana, Ariadne Malamitsi-Puchner
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia
Sep 17, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·May Lee TjoaInge J van Wijk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.