Decreased maximal aerobic capacity in pediatric chronic kidney disease

Journal of the American Society of Nephrology : JASN
Donald J WeaverMark M Mitsnefes

Abstract

Adult and pediatric patients with ESRD have impaired maximum oxygen consumption (VO(2) max), a reflection of the cardiopulmonary system's ability to meet increased metabolic demands. We sought to determine factors associated with decreased VO(2) max in pediatric patients with different stages of CKD. VO(2) max was measured using a standardized exercise testing protocol in patients with stage 2 to 4 chronic kidney disease (CKD) (n = 46), in renal transplant recipients (n = 22), in patients treated with maintenance hemodialysis (n = 12), and in age-matched healthy controls (n = 33). VO(2) max was similar between children with stage 2 CKD and controls, whereas lower VO(2) max was observed among children with stage 3 to 4 CKD, those treated with hemodialysis, and transplant recipients. In univariate analysis, VO(2) max was significantly associated with body mass index, resting heart rate, C-reactive protein, serum triglycerides, serum creatinine, and measures of diastolic function; no significant associations with left ventricular structure or systolic function were identified. In multivariate regression analysis, patient category versus control and the presence of diastolic dysfunction were independent predictors of lower VO(2) ma...Continue Reading

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Citations

Dec 3, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Donald J WeaverMark M Mitsnefes
Jan 30, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wai W CheungRobert H Mak
Aug 3, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Trine TangeraasAnna Bjerre
Jan 14, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Emma L ClappAlice C Smith
May 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Trine TangeraasAnna Bjerre
Sep 14, 2011·Nature Reviews. Nephrology·Rukshana ShroffMark M Mitsnefes
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Aug 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Riccardo LubranoMarco Elli
Aug 12, 2009·Transplantation·Christine B SethnaMary B Leonard
Mar 3, 2012·Journal of the American Society of Nephrology : JASN·Mark M Mitsnefes
Nov 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fabio PaglialongaAlberto Edefonti
Oct 8, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Monique van BergenMarc Lilien
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