Decreased mesopontine choline acetyltransferase levels in schizophrenia. Correlations with cognitive functions

Molecular and Chemical Neuropathology
C N KarsonW S Griffin

Abstract

The objective was to replicate a reported decrease of choline acetyltransferase (ChAT) in the mesopontine tegmentum of deceased schizophrenics and to see if such a decrease is related to their cognitive status as measured during life. Rigorous antemortem psychiatric evaluations were performed on our large population of schizophrenic patients. Mesopontine tissue was collected promptly following death from eight of these patients, from an additional five schizophrenics without systematic premortem psychiatric evaluation, and from control subjects. ChAT content of this brain tissue was determined using Western immunoblot analysis. There were 13 schizophrenic patients and 8 control subjects. The mean age of subjects in the two groups was similar (64 +/- 9 yr vs 63 +/- 10 yr). Even in the face of reduced post mortem intervals in the patients with schizophrenia, mesopontine tegmental ChAT concentrations were depressed by 70% in schizophrenic patients (1.28 +/- 1.74 vs 4.39 +/- 3.20 ng ChAT/micrograms tissue protein, P < 0.01), and correlated with orientation and reasoning (rs = 0.90 and 0.98, respectively) in those subjects assessed antemortem. Mesopontine ChAT concentrations are depressed in schizophrenia and correlate significantly...Continue Reading

References

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Citations

Oct 19, 2011·European Archives of Psychiatry and Clinical Neuroscience·Bianca VossTilo T J Kircher
Mar 30, 2001·Schizophrenia Research·R M KirraneL J Siever
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie K JonesMichael Bubser
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Dec 12, 2012·Expert Opinion on Investigational Drugs·Neelam ThakurathiDavid C Henderson
Mar 16, 2007·Current Medical Research and Opinion·Sylvie ChouinardHenri Cohen
Jul 22, 2004·Current Medical Research and Opinion·Nadège RipollMichel Bourin
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Emmanuel StipLuc Jean Boulay
Jun 29, 2004·Pharmacology, Biochemistry, and Behavior·Carrie K Jones, Harlan E Shannon
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Aug 30, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shahin AkhondzadehSams-Ali Rezazadeh

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