DOI: 10.1101/501163Dec 19, 2018Paper

Decreased metabolism and increased tolerability to extreme environment in Staphylococcus warneri with long-term space flight

BioRxiv : the Preprint Server for Biology
Po BaiChangting Liu

Abstract

Background:Many studies have shown that space environment can affect bacteria to cause a range of mutations. However, so far, there are less studies on the effects of long-term space flight (>1 month) on bacteria. In this study, a Staphylococcus warneri strain, which was isolated from the Shenzhou-10 spacecraft that had experienced a space flight (15-day), was carried into space again. After 64-day flight, the combined phenotypic, genomic, transcriptomic and proteomic analyses were performed to compare the influence of the two space flights on this bacteria. Results: Compared with short-term space flight, long-term space flight increased the biofilm formation ability of S. warneri and the cell wall resistance to external environment stress, but reduced the sensitivity to chemical stimulation. Further analysis showed that these changes might be related to the significantly up-regulated gene expression of phosphotransferase system, which regulated glucose metabolism pathway, including glucose, mannose, fructose and cellobiose. The mutation of S. warneri caused by 15-day space flight was limited at phenotype and gene level after ground culture. Conclusion: After a 79-day space flight, the changes of S. warneri are meaningful. Phos...Continue Reading

Related Concepts

Cell Wall
Environment
Food
Genes
Genome
Metabolism
Phosphotransferases
Up-Regulation (Physiology)
Anatomical Space Structure
Staphylococcus warneri

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