Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in a nonhuman primate model of aging

Neurobiology of Aging
Jignesh D PandyaPatrick G Sullivan

Abstract

Altered mitochondrial function in the basal ganglia has been hypothesized to underlie cellular senescence and promote age-related motor decline. We tested this hypothesis in a nonhuman primate model of human aging. Six young (6-8 years old) and 6 aged (20-25 years old) female Rhesus monkeys (Macaca mulatta) were behaviorally characterized from standardized video records. Additionally, we measured mitochondrial bioenergetics along with calcium buffering capacity in the substantia nigra and putamen (PUT) from both age groups. Our results demonstrate that the aged animals had significantly reduced locomotor activity and movement speed compared with younger animals. Moreover, aged monkeys had significantly reduced ATP synthesis capacity (in substantia nigra and PUT), reduced pyruvate dehydrogenase activity (in PUT), and reduced calcium buffering capacity (in PUT) compared with younger animals. Furthermore, this age-related decline in mitochondrial function in the basal ganglia correlated with decline in motor function. Overall, our results suggest that drug therapies designed to enhance altered mitochondrial function may help improve motor deficits in the elderly.

References

Feb 15, 1978·The Biochemical Journal·R G Hansford
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M J BannonG Kapatos
Sep 1, 1992·Mutation Research·D Harman
Apr 1, 1992·Brain : a Journal of Neurology·V M MannC D Marsden
Aug 1, 1990·Biological Reviews of the Cambridge Philosophical Society·Z A Medvedev
Sep 29, 1989·Biochemical and Biophysical Research Communications·Y MizunoY Kagawa
Jan 1, 1985·Annual Review of Biochemistry·Y Hatefi
Jun 10, 1988·Science·F A KingK G Gould
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Jan 1, 1995·Life Sciences·A C Bowling, M F Beal
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
May 1, 1993·Journal of Neurochemistry·A C BowlingM F Beal
Nov 1, 1995·Neurobiology of Aging·A OvadiaD M Gash
Oct 1, 1996·Annals of Neurology·R H SwerdlowW D Parker
Nov 20, 1998·The Journal of Comparative Neurology·M E EmborgJ H Kordower
Aug 7, 1999·Audiology & Neuro-otology·K K OhlemillerL L Dugan
Sep 2, 1999·Current Biology : CB·D Gems
Jan 27, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·W E SonntagA S Khan
Oct 18, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Z ZhangD Gash
Oct 18, 2000·Free Radical Biology & Medicine·E Cadenas, K J Davies
May 24, 2001·Critical Reviews in Biochemistry and Molecular Biology·E CarafoliM Brini
Jan 18, 2002·Journal of Neurochemistry·Greg A GerhardtDon M Gash
Jun 28, 2002·Physiological Reviews·Mark P MattsonWenzhen Duan
Nov 5, 2002·Trends in Biotechnology·Michael J Wolfgang, Thaddeus G Golos
Mar 28, 2003·The Journal of Biological Chemistry·Susan Chalmers, David G Nicholls
Jun 5, 2003·Annals of Neurology·Patrick G SullivanTallie Z Baram
Sep 13, 2003·Journal of Applied Physiology·Brian T Weinert, Poala S Timiras
Jul 1, 1956·Journal of Gerontology·D HARMAN
Jan 22, 2004·Nature Reviews. Neuroscience·Trey Hedden, John D E Gabrieli
Jan 30, 2004·Diabetes·Michael R Duchen
Jun 3, 2004·The Journal of Comparative Neurology·Patrick G SullivanStephen W Scheff
Jul 21, 2004·Journal of Neuroscience Methods·Maile R BrownOswald Steward
Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana Navarro, Alberto Boveris
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anatoly A StarkovM Flint Beal
Sep 21, 2004·Journal of Bioenergetics and Biomembranes·David G Nicholls, Susan Chalmers
Dec 2, 2004·Journal of Neuroscience Research·P G SullivanJ E Springer

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Citations

May 5, 2016·Neurobiology of Aging·Jignesh D PandyaPrasada Rao S Kodavanti
Apr 12, 2017·Journal of Neurochemistry·Amandine Grimm, Anne Eckert
Jan 18, 2017·Nature Communications·Julie A MattisonRozalyn M Anderson
Apr 10, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Birte SchmitzXiao-Qi Ding
Sep 30, 2017·Glia·Clare C Rittschof, Stefanie Schirmeier
Mar 3, 2018·The Journal of Experimental Biology·Clare C RittschofPatrick G Sullivan
Jun 12, 2018·Aging Cell·Mathieu PanelDidier Morin
May 29, 2018·Journal of Neurotrauma·Danielle N LyonsAdam D Bachstetter
May 3, 2019·Journal of Neuroscience Research·María F Harman, Mauricio G Martín
Oct 7, 2015·Metallomics : Integrated Biometal Science·Artur Dawid SurowkaMagdalena Szczerbowska-Boruchowska
Jan 1, 2020·International Journal of Molecular Sciences·Tomasz BoczekLudmila Zylinska
Apr 23, 2020·Journal of Aging Research·Jignesh D PandyaPrasada Rao S Kodavanti
May 13, 2018·Genes·Mario Rango, Nereo Bresolin
Oct 27, 2020·Frontiers in Aging Neuroscience·Nicholas S KronLynne A Fieber
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Hyunsu JungSeok-Kyu Kwon
Mar 7, 2021·Cells·Giulietta Di BenedettoKonstantinos Lefkimmiatis
Jun 7, 2018·Cell Metabolism·Mark P Mattson, Thiruma V Arumugam
Jun 3, 2021·International Journal of Molecular Sciences·Thayza Martins MelzerPatricia S Brocardo
Jun 14, 2021·Behavioral and Brain Functions : BBF·Aliabbas ZiaSaeed Samarghandian
Sep 28, 2021·American Journal of Physiology. Endocrinology and Metabolism·K Allison AmickAnthony J A Molina
Oct 4, 2021·Mechanisms of Ageing and Development·Yana BlinkouskayaJohannes Weickenmeier

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