Decreased mitochondrial fatty acid oxidation in placentas from women with preeclampsia

Placenta
J L BarthaG Perdomo

Abstract

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality in high and low-income countries. The aetiology of preeclampsia is multifactorial and remains obscure. Some evidences suggest that altered placental fatty acid oxidation might play a role in the pathogenesis of preeclampsia. To reveal if placental fatty acid oxidation is reduced in preeclampsia, we evaluate the expression levels of enzymes of mitochondrial fatty acid oxidation using quantitative Real-time PCR and the fatty acid oxidation rate in placental explants. We found that long-chain 3-hydroxyacyl-CoA dehydrogenase levels and fatty acid oxidation capacity were significantly reduced in placentas from women with preeclampsia.

References

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Citations

Apr 18, 2014·Antioxidants & Redox Signaling·Ludivine DoridotDaniel Vaiman
Dec 20, 2015·American Journal of Reproductive Immunology : AJRI·Lena ErlandssonStefan R Hansson
Nov 8, 2014·Molecular Human Reproduction·Dorothée PoidatzMarie-Noëlle Dieudonné
Jan 25, 2018·International Journal of Molecular Sciences·Sathish Kumar Natarajan, Jamal A Ibdah
Jan 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Amanda N Sferruzzi-PerriAbigail L Fowden
Feb 2, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Margaret Olutayo AleseThajasvarie Naicker
May 16, 2013·American Journal of Physiology. Endocrinology and Metabolism·Francisco VisiedoGermán Perdomo
Jun 3, 2016·Clinical Science·Cathal Michael McCarthy, Louise Clare Kenny
Nov 23, 2016·Lipids in Health and Disease·Jose L BarthaGermán Perdomo
Sep 22, 2016·Reproductive Sciences·Mareike SandvoßAnibh Martin Das
Nov 8, 2018·BioMed Research International·Rosa María MateosAlfonso M Lechuga-Sancho
Jun 22, 2018·Reviews in Endocrine & Metabolic Disorders·Suzan J G KnottnerusRiekelt H Houtkooper
Nov 11, 2020·Reproductive Sciences·Alejandra Abascal-SaizJosé L Bartha
Feb 2, 2021·Reproductive Sciences·Philippe VangriekenAlex H V Remels
Feb 3, 2021·The FEBS Journal·Mingyu HuChao Tong
Apr 1, 2017·Reproductive Sciences·Mareike SandvoßAnibh Martin Das
Mar 8, 2022·Current Hypertension Reports·Xiang-Qun Hu, Lubo Zhang

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