Decreased Monocyte HLA-DR Expression in Patients After Non-Shockable out-of-Hospital Cardiac Arrest

Shock
Fabienne VenetLaurent Argaud

Abstract

Out-of-hospital cardiac arrest (OHCA) constitutes a major health care problem with the development in immediate survivors of a post-cardiac arrest syndrome including systemic inflammatory response as observed in sepsis. As a decreased monocyte HLA-DR expression (mHLA-DR) has been repeatedly described in septic patients in association with an increased risk of death and nosocomial infections, we tested whether this immune alteration could also be observed after OHCA. Fifty-five non-shockable OHCA patients sampled at Day 0 (D0: within 4 h after OHCA), D1 (the next day), and D3: (after 2 additional days) were included. CD4+ lymphocyte count and mHLA-DR were evaluated by flow cytometry. We observed a marked decrease in mHLA-DR as early as D0 in patients compared with normal values. This decrease persisted till D3 and was associated with a moderate decrease in the number of circulating CD4+ lymphocytes. No correlations were identified between mHLA-DR and usual prognostic markers after OHCA. However, overtime evolution in mHLA-DR values appeared different between survivors and non-survivors with a quasisystematic decrease between D1 and D3 in non-survivors versus an increased expression in survivors. In conclusion, this preliminary p...Continue Reading

References

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Citations

Jun 15, 2016·Shock·Mark G Clemens
Aug 16, 2017·Annals of Intensive Care·Paola VilloisFabio Silvio Taccone
Nov 21, 2018·Intensive Care Medicine·Peter Pickkers, Tom van der Poll
Oct 25, 2017·Intensive Care Medicine Experimental·Carmen Andrea PfortmuellerJoerg C Schefold
Nov 7, 2019·BMC Infectious Diseases·Didier PayenAnne Claire Lukaszewicz
Apr 10, 2019·Annals of Intensive Care·Martin CourLaurent Argaud
Jun 27, 2019·Journal of the American Heart Association·Sergey RyzhovDavid B Seder

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

GraphPad Prism

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