PMID: 9548197Apr 21, 1998Paper

Decreased myocardial accumulation of 123I-meta-iodobenzyl guanidine in Parkinson's disease

Nuclear Medicine Communications
Mitsuhiro YoshitaS Hirai

Abstract

The aim of this study was to evaluate 123I-meta-iodobenzyl guanidine (123I-MIBG) myocardial scintigraphy in patients with Parkinson's disease as a way of detecting cardiac sympathetic dysfunction, and comparing the stage of disease and intensity of drug treatment with accumulation of 123I-MIBG. 123I-MIBG myocardial scintigraphy was performed in 48 patients with Parkinson's disease and 25 control subjects. In the planar imaging studies, the data acquisition matrix was 256 x 256 and the preset time was 5 min. The heart-to-mediastinum (H/M) average count ratio was calculated for both early (15 min) and delayed (3-4 h) images after 123I-MIBG injection (111 MBq). The mean H/M ratio in patients with Parkinson's disease was significantly lower than that in the controls (P < 0.0001). Regardless of disease severity, intensity of anti-Parkinson treatment and the presence or absence of orthostatic hypotension, the mean H/M ratios were always low in the Parkinsonian patients. Parkinson's disease may result in a severe abnormality of cardiac sympathetic function which has not been detected by previous cardiovascular autonomic studies.

Citations

Sep 1, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kenji SakaiMasahito Yamada
Feb 16, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S Goldstein
Jul 20, 2002·Journal of the Neurological Sciences·Samir M ParikhDavid Robertson
Oct 24, 2003·Lancet Neurology·David S Goldstein
Jul 7, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H OkaS Mochio
Oct 1, 2009·Journal of Movement Disorders·Juha O Rinne
Mar 4, 2005·Pathology International·Masayuki SugieHidekazu Ota
Nov 9, 2011·The International Journal of Neuroscience·Charles H Adler
Apr 14, 2016·Current Neurology and Neuroscience Reports·Per BorghammerDavid J Brooks
Jun 20, 2015·Journal of Movement Disorders·Eun Joo Chung, Sang Jin Kim
Mar 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Nicola PavesePaola Piccini
Jul 9, 2004·Annals of the New York Academy of Sciences·David S Goldstein
Jul 2, 2003·Hypertension·David S GoldsteinYehonatan Sharabi
Nov 22, 2011·Neurologia i neurochirurgia polska·Marta Leńska-MieciekPiotr Kułakowski
Nov 3, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Aldo QuattroneFrancesca Condino
Oct 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Fabiana NovellinoAldo Quattrone
Oct 31, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Olivier Rascol, Ludwig Schelosky
Apr 13, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Jörg SpiegelUlrich Dillmann
Jun 6, 2009·Expert Review of Neurotherapeutics·Daniel D Truong, Erik C Wolters
Jun 14, 2003·The Journal of Pharmacology and Experimental Therapeutics·David S GoldsteinKrys Bankiewicz
Jan 13, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Jörg SpiegelCarl-Martin Kirsch
Jun 27, 2017·NPJ Parkinson's Disease·Per BorghammerDavid J Brooks
Feb 5, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Mutsumi IijimaShinichiro Uchiyama
May 30, 2017·Rinshō shinkeigaku = Clinical neurology·Satoshi Orimo
Sep 21, 2018·Current Neurology and Neuroscience Reports·Karoline Knudsen, Per Borghammer
Jan 21, 2021·Journal of Functional Morphology and Kinesiology·Andrew E PechsteinAndrew A Guccione
Mar 12, 2010·Nuclear Medicine Communications·Linda van der VeenMarcel Stokkel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.