Decreased N-acetylaspartate in children with familial bipolar disorder

Biological Psychiatry
Kiki ChangT A Ketter

Abstract

Relatively low levels of brain N-acetylaspartate, as measured by magnetic resonance spectroscopy, may indicate decreased neuronal density or viability. Dorsolateral prefrontal levels of N-acetylaspartate have been reported to be decreased in adults with bipolar disorder. We used proton magnetic resonance spectroscopy to investigate dorsolateral prefrontal N-acetylaspartate levels in children with familial bipolar disorder. Subjects were 15 children and adolescents with bipolar disorder, who each had at least one parent with bipolar disorder, and 11 healthy controls. Mean age was 12.6 years for subjects and controls. Subjects were allowed to continue current medications. Proton magnetic resonance spectroscopy at 3-Tesla was used to study 8 cm(3) voxels placed in left and right dorsolateral prefrontal cortex. Bipolar subjects had lower N-acetylaspartate/Creatine ratios only in the right dorsolateral prefrontal cortex (p <.02). No differences in myoinositol or choline levels were found. Children and adolescents with bipolar disorder may have decreased dorsolateral prefrontal N-acetylaspartate, similar to adults with BD, indicating a common neuropathophysiology. Longitudinal studies of at-risk children before the onset and during t...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Oct 1, 1977·Archives of General Psychiatry·N C AndreasenG Winokur
Sep 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·V DelvenneJ Mendlewicz
Oct 1, 1990·The American Journal of Psychiatry·J L MartinotA Syrota
Sep 1, 1989·Psychiatry Research·F M ReischiesR Drochner
Mar 1, 1989·Archives of General Psychiatry·L R BaxterR M Sumida
Sep 1, 1995·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·M A FristadE B Weller
Apr 24, 1997·Nature·W C DrevetsM E Raichle
Aug 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·S V FaraoneD O'Donnell
Dec 31, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A BertolinoD R Weinberger
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·D OngürJ L Price
Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A PfefferbaumK O Lim
Mar 15, 2000·Biological Psychiatry·M E WinsbergT A Ketter
Feb 22, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P DavanzoJ McCracken
Mar 16, 2001·Bipolar Disorders·D A Yurgelun-ToddA D Young
Feb 5, 2002·Archives of General Psychiatry·Carla L NolanDavid R Rosenberg
Apr 18, 2002·Biological Psychiatry·Kelly N BotteronRichard D Todd
Jul 13, 2002·Biological Psychiatry·Tiffany R FarchioneDavid R Rosenberg

❮ Previous
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Citations

Apr 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Tomas HajekMartin Alda
Mar 29, 2013·Brain Imaging and Behavior·Shelli R KeslerJeffrey S Wefel
Nov 13, 2004·Current Psychiatry Reports·Melissa P Delbello, Stephen M Strakowski
Jan 29, 2008·Current Psychiatry Reports·Lisa D TownsendRobert L Findling
Aug 9, 2005·Biological Psychiatry·Kiki ChangAllan L Reiss
Sep 14, 2013·Psychiatry Research·Manpreet K SinghKiki D Chang
Oct 27, 2006·Development and Psychopathology·Daniel P Dickstein, Ellen Leibenluft
Oct 27, 2006·Development and Psychopathology·Kiki ChangAmy Garrett
Oct 8, 2008·Development and Psychopathology·Amy Garrett, Kiki Chang
Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melissa P DelBelloStephen M Strakowski
Oct 4, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert J SchloesserHusseini K Manji
Feb 1, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jorge A QuirozHusseini K Manji
Feb 24, 2009·Journal of Child and Adolescent Psychopharmacology·Daniel P DicksteinEllen Leibenluft
Aug 2, 2012·Journal of Child and Adolescent Psychopharmacology·Kiki ChangStephen M Strakowski
Sep 15, 2005·Current Opinion in Pediatrics·Sencan Solay UnalDavid A Mrazek
Dec 18, 2003·Psychiatry and Clinical Neurosciences·Hiroshi HamakawaTadafumi Kato
Apr 3, 2009·The Journal of Clinical Investigation·Keri MartinowichHusseini K Manji
Feb 22, 2014·AJNR. American Journal of Neuroradiology·D G KondoP F Renshaw
Sep 8, 2007·Journal of Child and Adolescent Psychopharmacology·Rene L OlveraJair C Soares
Oct 9, 2012·Child and Adolescent Psychiatric Clinics of North America·Manpreet K Singh, Kiki D Chang
Oct 13, 2009·Journal of Psychiatric Research·Fabiano G NeryJair C Soares
Mar 7, 2009·Child and Adolescent Psychiatric Clinics of North America·Janine TerryJean A Frazier
Apr 12, 2008·Psychiatry Research·Daniel P DicksteinEllen Leibenluft
Jan 18, 2008·Neuroscience and Biobehavioral Reviews·Flavio KapczinskiRobert M Post
Jan 24, 2007·Journal of Psychiatric Research·Robert M Post
Oct 19, 2007·Acta Psychiatrica Scandinavica. Supplementum·G S MalhiP Sachdev
Jul 15, 2009·Bipolar Disorders·Thilo DeckersbachDarin D Dougherty
Jun 6, 2007·Bipolar Disorders·Christoph U CorrellBarbara A Cornblatt
Apr 14, 2007·Bipolar Disorders·Paolo BrambillaJair C Soares
Jan 13, 2006·Bipolar Disorders·Kim A GallelliKiki D Chang
Jan 21, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Nurit Yirmiya, Tony Charman
Sep 24, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Morgan Haldane, Sophia Frangou
Apr 14, 2005·The Psychiatric Clinics of North America·Paolo BrambillaJair C Soares
Sep 24, 2015·European Child & Adolescent Psychiatry·Xavier BenarousDavid Cohen
Jan 19, 2005·Bipolar Disorders·Peter H SilverstoneHyeonjin Kim
Mar 12, 2008·Bipolar Disorders·Eric A YoungstromRobert L Findling
Oct 18, 2006·Bipolar Disorders·M Elizabeth SubletteJ John Mann

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