PMID: 3764338Aug 1, 1986Paper

Decreased natural killer cell activity versus normal natural killer cell markers in mononuclear cells from patients with smouldering leukemia

Scandinavian Journal of Haematology
D SørskaarP Stavem

Abstract

Peripheral blood (PB) and bone marrow mononuclear cells from 23 patients with smouldering leukemia were analyzed for natural killer (NK) cell activity and various surface cell markers. Significantly reduced NK activity was detected in the patients' PB compared with the activity in the healthy controls (p less than 0.0005). A similar difference in NK cell activity between the 2 groups was also observed in bone marrow mononuclear cells (p = 0.005). In contrast, no significant differences in cells positive for the NK cell markers Leu-7 and Leu-11b were found between patients and controls, either in PB or in bone marrow. The patients' PB and bone marrow mononuclear cells had, however, a reduced percentage and absolute number of Leu 3a+ and T8+ cells. Patients with smouldering leukemia have immunological derangements which may make them predisposed for the later development of florid leukemia.

References

Jan 1, 1972·Scandinavian Journal of Immunology·S S Fröland
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May 28, 1981·Nature·C S HenneyS Gillis
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Citations

Jan 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H M OgmundsdóttirO Jensson
Aug 1, 1994·Scandinavian Journal of Immunology·H M OgmundsdóttirH M Ogsmundsdóttir
Jun 13, 2000·Bone Marrow Transplantation·B SimonssonB I Nilsson
Sep 1, 1990·European Journal of Haematology·A OsterborgH Mellstedt

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