Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance

Diabetologia
C D ByrneC N Hales

Abstract

To investigate causes of increased triglyceride concentrations in subjects with normal glucose tolerance (determined by oral glucose tolerance testing using World Health Organization criteria) 883 healthy subjects (389 men and 494 women) between 40 and 65 years of age were studied. Subjects were divided by gender into four groups according to 120-min glucose concentrations. Individuals in the highest quartile of glucose concentration had the highest mean triglyceride concentrations (p < 0.0001) and highest mean non-esterified fatty acid (NEFA) concentrations (p < 0.0001). There was also a clustering of cardiovacular risk factors normally associated with the insulin resistance syndrome in subjects in this group. Regression analysis showed that the most important determinants of triglyceride levels were smoking (men p = 0.001, women p = 0.005), waist:hip ratio (men p = 0.01, women p < 0.001) and NEFA suppression (men p = 0.02, women p = 0.005). NEFAs suppressed 16.7% in women compared to 2.4% in men during the first 30 min of the oral glucose tolerance test (p < 0.001). These results show that a clustering of cardiovascular risk factors associated with decreased NEFA suppression occurs in a sub-group of subjects with normal gluco...Continue Reading

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Citations

Jun 20, 2001·Diabetes, Obesity & Metabolism·A J Stears, C D Byrne
Jul 1, 1997·The Proceedings of the Nutrition Society·K N FraynB A Fielding
Dec 15, 1996·European Journal of Biochemistry·O D MadsenP Serup
Oct 19, 2011·Biochimica Et Biophysica Acta·Savitha Subramanian, Alan Chait
May 1, 1998·Molecular Genetics and Metabolism·F BelfioreG Volpicelli
Mar 17, 1999·Journal of the Royal Society of Health·D P MikhailidisE S Ganotakis
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D J HalsallS O'Rahilly
Jun 26, 2001·European Journal of Clinical Nutrition·L HåglinL O Bygren
Feb 27, 2004·Diabetes, Obesity & Metabolism·Andrew J Krentz

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