PMID: 2496890Feb 20, 1989Paper

Decreased norepinephrine in the ventral lamina terminalis region is associated with angiotensin II drinking response deficits following local 6-hydroxydopamine injections

Brain Research
J T Cunningham, A K Johnson

Abstract

Previous studies have demonstrated that punctate injections of 6-hydroxydopamine (6-OHDA) into structures along the ventral lamina terminalis reduce drinking responses elicited by angiotensin II (ANG II). The purpose of the present study was to extend these findings by quantifying the catecholamine depletions that are associated with the drinking response deficits. Male Sprague-Dawley rats were given injections of 6-OHDA into the median preoptic nucleus (MnPO) and the organum vasculosum of the lamina terminalis (OVLT) after pretreatment with pargyline. Controls were injected with vehicle and a third group received 6-OHDA after pretreatment with desmethylimipramine (DMI). All subjects were tested for drinking responses to centrally injected ANG II and carbachol. Changes in catecholamine content of the MnPO, OVLT, supraoptic nucleus, paraventricular nucleus, caudate and cortex were determined using HPLC with electrochemical detection after behavioral testing. Only rats injected with 6-OHDA without DMI pretreatment showed a significant reduction in ANG II-induced drinking responses. This behavioral deficit was associated with a significant norepinephrine decrease in the ventral lamina terminalis region. All 3 groups showed compara...Continue Reading

References

May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Jan 1, 1984·Journal of Neural Transmission·T A Reader, P Gauthier
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·R W Fuller

❮ Previous
Next ❯

Citations

Apr 28, 2004·Autonomic Neuroscience : Basic & Clinical·Kazuhiro SakamakiJunichi Tanaka
Oct 8, 2003·Behavioural Brain Research·Hiroko MiyakuboJunichi Tanaka
May 20, 2003·Brain Research Bulletin·Junichi TanakaMasahiko Nomura
Jun 1, 2000·Clinical and Experimental Pharmacology & Physiology·S L Bealer
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·A K JohnsonR L Thunhorst
Nov 15, 2006·The European Journal of Neuroscience·Lawrence P CarterCharles P France
Jul 8, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Wilson A SaadJ Antunes Rodrigues
Apr 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A SaadW A Saad
Sep 1, 2008·Journal of the American Society of Hypertension : JASH·Wilson Abrão SaadTalmir Augusto Faria Brizola Dos Santos
Jan 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miloslav Kolaj, Leo P Renaud
Feb 18, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandria B MarcianteJ Thomas Cunningham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.