PMID: 3773519Oct 1, 1986Paper

Decreased nuclear binding of estrogen receptors in the pituitary of mice: correlation with biological effects throughout aging

Journal of Steroid Biochemistry
S BelisleD Bellabarba

Abstract

We have determined the biological impact of our previously reported decreased activation of pituitary E2 receptors (PER) in mice. Young (4-8 months), middle-aged (10-14 months) and aged (15-18 months) female mice were studied either intact (metestrous) or gonadectomized (ovx) for 2 weeks prior to decapitation. Recombination studies using heat-treated cytosolic PER and enriched nuclear fractions of various age groups showed a markedly reduced ability for nuclear binding with advancing age, despite unchanged affinity of activated PER for nuclear acceptor sites. Cross incubation studies of heat-activated cytosolic PER with nuclei from mice of various age groups suggested that the activation defect followed the onset of anestrous whereas a reduced nuclear ability to support receptor binding preceded this manifestation. In parallel with these endocrine changes we observed a decrease in baseline cytosolic progesterone receptor (RcP) concentration and in the activity of the enzyme G6PDH in intact aging mice. Ovx induced a further decrease of both markers in young and middle-aged, but not in old mice, while E2 administration induced a decreased pituitary response in RcP but not in G6PDH in aged mice. Our results suggest functional chan...Continue Reading

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Citations

Jun 1, 1994·Journal of Cellular Biochemistry·J P LandersT C Spelsberg
Mar 15, 1990·Mechanisms of Ageing and Development·S BelisleJ G Lehoux
Sep 1, 1989·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S BelisleJ G Lehoux

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