Decreased number and bactericidal activity against Staphylococcus aureus of the resident cells in milk of dairy cows during early lactation

The Journal of Dairy Research
H DosogneC Burvenich

Abstract

Phagocytic and bactericidal activity of polymorphonuclear neutrophil leukocytes (PMN) isolated from blood and milk, against Staphylococcus aureus, was compared between groups of six healthy dairy cows in early, mid- and late lactation using a bacteriological assay. PMN were isolated from blood with a high degree of purity, but the cells isolated from milk contained variable amounts of macrophages (Mphi) and lymphocytes (L). The results were therefore calculated using the percentage PMN in order to evaluate phagocytosis and killing by PMN only. Blood PMN phagocytosed 82% Staph. aureus and milk PMN 43% on average and there was no significant difference between the different stages of lactation. The bactericidal activity of blood PMN against Staph. aureus was 36+/-8% in early lactation (significantly different from mid lactation, P < 0.05), 64+/-10% in mid lactation and 53+/-6% in late lactation. Milk PMN killed only 6+/-3% Staph. aureus in early lactation (significantly different from mid lactation, P < 0.01), 27+/-3% in mid lactation and 20+/-9% Staph. aureus in late lactation. The ratio of the bactericidal activity of milk to blood PMN was 0.08, 0.43 and 0.22 in early, mid- and late lactation, respectively. In addition to the d...Continue Reading

Citations

Dec 24, 2008·Tropical Animal Health and Production·A K DangCharan Singh
Aug 19, 2007·The Journal of Dairy Research·Fabrizio CecilianiPaola Sartorelli
Sep 1, 2004·American Journal of Veterinary Research·Araceli Diez-FrailleChristian Burvenich
Apr 11, 2008·Veterinary Immunology and Immunopathology·Katsuro HagiwaraJunichi Ando
Jul 16, 2010·Journal of Animal Physiology and Animal Nutrition·A K DangS Prasad
Jul 21, 2004·Journal of Dairy Science·F VangroenwegheC Burvenich
May 29, 2018·Journal of Dairy Science·P RainardR Rupp

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