PMID: 3748463Aug 15, 1986Paper

Decreased numbers of dendritic spines on cortical pyramidal neurons in human chronic alcoholism

Neuroscience Letters
I FerrerE Galofré

Abstract

Samples of the cerebral cortex (left hemisphere, area 6) were collected at autopsy, between 4 and 6 h after death in order to avoid artifacts related to fixation delay, from 5 chronic alcoholic patients (in which well-defined alcoholic-malnutritional encephalopathies were excluded) and 16 controls; samples were immediately processed according to the rapid Golgi method. The curves representing the average density of dendritic spines on the apical dendrites of layer V pyramidal neurons as a function of the distance from the cell body were adjusted to a logarithmical model which was shown to be similar in controls and alcoholic groups. Significant reduced numbers of dendritic spines were observed; however, in the alcoholic patients when compared to age-matched controls (P less than 0.001; Kruskall-Wallis chi 2 test). These results demonstrate noxious effects of ethanol on cortical pyramidal neurons in human chronic alcoholism.

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Citations

Jan 1, 1990·Acta Neuropathologica·I Ferrer, F Gullotta
Jan 1, 1995·Journal of Neural Transmission. General Section·K MannP Wakat
Nov 13, 1993·Lancet·G B Jensen, B Pakkenberg
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Aug 21, 2007·Expert Review of Proteomics·Izuru MatsumotoHaruka Matsuda-Matsumoto
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Mar 9, 2021·Brain Plasticity·Ibdanelo CortezJ Leigh Leasure

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