Decreased numbers of T-lymphocytes and predominance of recently recruited macrophages in the walls of peripheral pulmonary arteries from 26 patients with pulmonary hypertension secondary to congenital cardiac shunts

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Rubens Fraga Alves PintoVera Demarchi Aiello

Abstract

In the primary form of pulmonary hypertension (PH), the involvement of inflammation in the physiopathology of the vascular lesions is well established. Its role in secondary PH is yet to be investigated. We quantified the inflammatory cells on the walls of peripheral pulmonary arteries from patients with congenital heart shunts. Twenty-six lung biopsies from patients with increased pulmonary flow and 10 lung fragments from control participants were examined. B-lymphocytes (CD20), T-lymphocytes (CD3), recently recruited macrophages (MAC387) and granulocytes (CD15) were quantified by area of the adventitia in arteries >50 microm. An index of inflammatory cells infiltrating the medial and intimal layers was also determined. There was no difference in the sum of densities of adventitial inflammatory cells between the groups. A prevalence of MAC387-labeled cells was detected in the PH group and of CD3-labeled cells in the controls. There was a lower density of T-lymphocytes in the PH group (P<.004). Patients with intimal proliferative lesions showed prevalence of MAC387-labeled cells (P=.004). PH participants showed a higher index of MAC387-labeled cells infiltrating the arterial medial and intimal layers (P<.001). The predominance ...Continue Reading

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Citations

May 26, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Danielle L BurkeKurt R Stenmark
Jan 5, 2012·Chest·Laura C PriceMarc Humbert
Jun 5, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David J RossJohn A Belperio
Nov 10, 2012·Arthritis Care & Research·Yukiko KimuraUNKNOWN Childhood Arthritis Rheumatology Research Alliance Carra Net Investigators
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Jun 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S S PullamsettiR T Schermuly
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Feb 2, 2013·Pulmonary Circulation·Mita DasJames West
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Mar 28, 2006·Physiology·Kurt R StenmarkMita Das
Mar 29, 2014·Journal of Hypertension·Elsa C ChanFan Jiang
Jul 20, 2019·American Journal of Respiratory and Critical Care Medicine·Jun-Bean ParkSeung-Pyo Lee
Sep 23, 2016·Mediators of Inflammation·Leína ZorzanelliAntonio Augusto Lopes
Nov 28, 2019·International Journal of Molecular Sciences·Ana I FernándezJavier Bermejo

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