PMID: 19568Sep 1, 1977

Decreased opsonization for Streptococcus pneumoniae in sickle cell disease: studies on selected complement components and immunoglobulins

The Journal of Pediatrics
A B BjornsonC L Zellner

Abstract

Opsonic activity for Streptococcus pneumoniae in the sera of patients with sickle cell disease was reduced in comparison to the opsonic activity of sera from age-matched normal children. No difference in opsonic activity for Escherichi coli was observed in the sera from patients or normals. Total hemolytic complement, conversion of C3 by inulin and cobra venom factor, and levels of C3, factor B, properdin, C3b inactivator, and immunoglobulins G, A, and M were normal in patients' sera. The opsonic abnormality for S. pneumoniae was attributed to a deficiency of serum proteins rather than to an inhibitor of opsonic function. The data suggest that decreased opsonization was not associated with a deficiency of those complement components or immunoglobulins measured in this study.

References

Apr 19, 1973·The New England Journal of Medicine·R B JohnstonA G Struth
Dec 1, 1968·American Journal of Diseases of Children·H E Evans, C Reindorf
Jan 1, 1972·American Journal of Diseases of Children·R A SeelerM A Mufson
Jan 1, 1972·Acta Haematologica·N V DimitrovM A Toth
Feb 1, 1972·Pediatric Research·A D Schwartz, H A Pearson
May 5, 1966·The New England Journal of Medicine·M G Robinson, R J Watson

Citations

Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J R HumbertJ B Schmitz
May 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C M MooreR U Sorensen
Jun 1, 1994·Clinical Otolaryngology and Allied Sciences·S O Ajulo
May 1, 1982·Archives of Disease in Childhood·V F LarcherR Williams
Dec 1, 1991·Immunological Investigations·S TaylorG Dinkins
Jan 1, 1984·Critical Reviews in Microbiology·J A Winkelstein
Jun 1, 1984·Annals of Tropical Paediatrics·A MallouhM S Ahmad
Jan 1, 1986·Annals of Saudi Medicine·M A El-Hazmi
Jan 1, 1986·Pediatric Hematology and Oncology·D L BectonT R Kinney
Aug 1, 1988·American Journal of Hematology·W C WangR J Wyatt
Jun 1, 1988·Annals of Tropical Paediatrics·I el ArabiJ Acquaye

Related Concepts

Teens
Anemia, Sickle Cell
Hemolytic Complement
Complement C3 precursor
Enzyme Precursors
Alkalescens-Dispar Group
Neoglycoproteins
IgA2
IgG2B
IgM2

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